SA-2 Antibody (B-11): sc-376026
- SA-2 Antibody (B-11) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1137-1175 near the C-terminus of SA-2 of human origin
- recommended for detection of SA-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SA-2 Antibody (B-11) for WB applications. This reagent is now offered in a bundle with SA-2 Antibody (B-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
SA-2 Antibody (B-11) is a mouse monoclonal IgG3 antibody that detects SA-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SA-2, also known as STAG2, is a crucial 1,231 amino acid component of the cohesion complex, which plays a vital role in ensuring proper cohesion of sister chromatids following DNA replication. SA-2 is localized in the nucleus, where SA-2 associates with chromatin, facilitating the organization and separation of chromosomes during cell division. Upon phosphorylation by polo-like kinase (Plk), SA-2 dissociates from chromatin, a critical step that allows for accurate chromosome segregation during anaphase, thereby preventing genomic instability. Additionally, SA-2 has been shown to enhance the activity of tumor necrosis factor alpha (TNFα) and may function as a putative transcriptional regulator, highlighting SA-2′s importance not only in cell division but also in cellular signaling pathways. Anti-SA-2 antibody (B-11) is an essential tool for researchers studying the dynamics of chromatin organization and the mechanisms underlying cell cycle regulation.
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SA-2 Antibody (B-11) References:
- STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma. | Surdez, D., et al. 2021. Cancer Cell. 39: 810-826.e9. PMID: 33930311
- STAG2 promotes the myelination transcriptional program in oligodendrocytes. | Cheng, N., et al. 2022. Elife. 11: PMID: 35959892
- An active domain SA-2 derived from cystatin-SA, and its antifungal activity. | Liu, X., et al. 2023. Amino Acids. 55: 101-112. PMID: 36333524
- STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells. | Li, X., et al. 2023. Cell Death Dis. 14: 454. PMID: 37479689
- STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme. | Xu, W., et al. 2024. J Biol Chem. 300: 107341. PMID: 38705393
- Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk. | Kimura, S., et al. 2024. Cancer Discov. 14: 1838-1859. PMID: 38916500
- STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia. | Fischer, A., et al. 2024. Cell Rep. 43: 114498. PMID: 39084219
- Untangling the loops of STAG2 mutations in myelodysplastic syndrome. | Sudunagunta, VS. and Viny, AD. 2025. Leuk Lymphoma. 66: 6-15. PMID: 39264305
- Emerging roles of cohesin-STAG2 in cancer. | Scott, JS., et al. 2025. Oncogene. 44: 277-287. PMID: 39613934
- A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis. | Ashkin, EL., et al. 2025. J Exp Med. 222: PMID: 39652422
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SA-2 Antibody (B-11) | sc-376026 | 200 µg/ml | $322.00 | |||
SA-2 Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-522823 | 200 µg Ab, 40 µg BP | $361.00 | |||
SA-2 (B-11) Neutralizing Peptide | sc-376026 P | 100 µg/0.5 ml | $69.00 |