S-100 beta chain Antibody (G-9): sc-398707

S-100 β chain Antibody (G-9) is a mouse monoclonal IgG1 antibody that detects S-100 β chain in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). S-100 β chain is a member of the S-100 protein family, which plays a crucial role in various cellular processes, including the regulation of cell cycle progression and differentiation. S-100 β chain (G-9) antibody helps identify this protein′s involvement in calcium signaling pathways, where S-100 β chain can activate calcium-induced calcium release, thereby influencing cellular responses to calcium fluctuations. S-100 β chain is primarily localized in the cytoplasm and nuclei of astrocytes, Schwann cells, and certain tumors, such as ependymomas and astrogliomas, highlighting its significance in both normal and pathological states of the nervous system. The presence of S-100 β chain in benign and malignant melanocytic tumors, as well as in Langerhans cells in the skin, further underscores its potential as a biomarker in cancer research. Anti-S-100 β chain antibody (G-9) is an essential tool for researchers investigating the roles of S-100 proteins in health and disease, providing insights into their functions and interactions within various biological contexts.

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S-100 beta chain Antibody (G-9) References:

1. Autocrine S100B effects on astrocytes are mediated via RAGE.  |  Ponath, G., et al. 2007. J Neuroimmunol. 184: 214-22. PMID: 17254641
2. S100B in underweight and weight-recovered patients with anorexia nervosa.  |  Ehrlich, S., et al. 2008. Psychoneuroendocrinology. 33: 782-8. PMID: 18423888
3. Causes of elevated serum levels of S100B protein in athletes.  |  Donato, R., et al. 2013. Eur J Appl Physiol. 113: 819-20. PMID: 23241954
4. Clinical use of the calcium-binding S100B protein.  |  Astrand, R., et al. 2013. Methods Mol Biol. 963: 373-84. PMID: 23296623
5. Polymorphisms in DCDC2 and S100B associate with developmental dyslexia.  |  Matsson, H., et al. 2015. J Hum Genet. 60: 399-401. PMID: 25877001
6. Serum S100B level may be correlated with carbon monoxide poisoning.  |  Liu, H., et al. 2015. Int Immunopharmacol. 27: 69-75. PMID: 25925764
7. Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure.  |  Fırat Oğuz, E., et al. 2018. Turk J Med Sci. 48: 449-454. PMID: 29914235
8. S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53.  |  Yang, T., et al. 2018. Oncol Rep. 40: 1574-1582. PMID: 29956807
9. The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation.  |  Cristóvão, JS., et al. 2018. Sci Adv. 4: eaaq1702. PMID: 29963623
10. Levels of S100 calcium binding protein B (S100B), neuron-specific enolase (NSE), and cyclophilin A (CypA) in the serum of patients with severe craniocerebral injury and multiple injuries combined with delirium transferred from the ICU and their prognostic value.  |  Gao, Y., et al. 2021. Ann Palliat Med. 10: 3371-3378. PMID: 33849122

The preferred S-100 α/β chain antibody is S-100 α/β chain Antibody (B32.1): sc-58839.