RXRβ Antibody (MOK13-17): sc-56869

RXRβ Antibody (MOK13-17) is a mouse monoclonal IgG1 kappa light chain antibody that detects RXRβ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RXRβ antibody (MOK13-17) is available as a non-conjugated format. RXRβ protein plays a crucial role in gene expression regulation as a member of the retinoid X receptor family, which mediates retinoic acid effects, a vitamin A derivative. RXRβ protein localizes primarily in the nucleus, functioning as a transcription factor that forms heterodimers with other nuclear receptors, such as retinoic acid receptors (RARs) and thyroid hormone receptors. RXRβ interaction with these receptors is vital for regulating various biological processes, including development, differentiation, and metabolism. RXRβ protein modulates cellular responses to retinoids, which maintain normal physiological functions and prevent diseases. RXRβ family is characterized by highly conserved DNA-binding and ligand-binding domains, critical for function and specific ligand interaction, making RXRβ protein a significant target for research in cancer, metabolic disorders, and developmental biology.

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RXRβ Antibody (MOK13-17) References:

1. RXR beta isoforms in neuroblastoma cells and evidence for a novel 3'-end transcript.  |  Rana, B., et al. 2001. FEBS Lett. 506: 39-44. PMID: 11591367
2. H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.  |  Marks, MS., et al. 1992. EMBO J. 11: 1419-35. PMID: 1314168
3. Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma.  |  Hoopes, CW., et al. 1992. Genomics. 14: 611-7. PMID: 1358808
4. Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation.  |  Hallenbeck, PL., et al. 1992. Proc Natl Acad Sci U S A. 89: 5572-6. PMID: 1608968
5. RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements.  |  Yu, VC., et al. 1991. Cell. 67: 1251-66. PMID: 1662118
6. Isolation of a novel RXR from Xenopus that most closely resembles mammalian RXR beta and is expressed throughout early development.  |  Marklew, S., et al. 1994. Biochim Biophys Acta. 1218: 267-72. PMID: 8049252
7. The mouse Rxrb gene encoding RXR beta: genomic organization and two mRNA isoforms generated by alternative splicing of transcripts initiated from CpG island promoters.  |  Nagata, T., et al. 1994. Gene. 142: 183-9. PMID: 8194750
8. Abnormal spermatogenesis in RXR beta mutant mice.  |  Kastner, P., et al. 1996. Genes Dev. 10: 80-92. PMID: 8557197
9. Differential 9-cis-retinoic acid-dependent transcriptional activation by murine retinoid X receptor alpha (RXR alpha) and RXR beta. Role of cell type and RXR domains.  |  Hallenbeck, PL., et al. 1996. J Biol Chem. 271: 10503-7. PMID: 8631847
10. RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.  |  Krezel, W., et al. 1996. Proc Natl Acad Sci U S A. 93: 9010-4. PMID: 8799145

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RXRβ Antibody (MOK13-17) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-RXRβ Antibody (MOK13-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RXRβ Antibody (MOK13-17) Specifications

Alternate Product Name: RXRβ

Product Clone Name: MOK13-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: RXRβ

Epitope Species: human

Product Reactivity/Detection: RXRβ₁ and RXRβ₂

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for RXRβ Antibody (MOK13-17): N/A