RXRα Antibody (H-10): sc-515929

RXRα Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects RXRα protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RXRα antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RXRα protein plays a crucial role in the regulation of gene expression as a nuclear receptor that forms heterodimers with other nuclear receptors, such as retinoic acid receptors (RARs) and thyroid hormone receptors, thereby influencing various physiological processes including development, metabolism, and cellular differentiation. RXRα′s ability to interact with multiple ligands, including 9-cis-retinoic acid, highlights RXRα′s importance in mediating the effects of retinoids and other signaling molecules, making RXRα a key player in maintaining homeostasis and responding to environmental changes. Understanding RXRα function is vital for elucidating RXRα′s role in diseases such as cancer and metabolic disorders, where dysregulation of nuclear receptor signaling can lead to pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RXRα Antibody (H-10) References:

1. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha.  |  Levin, AA., et al. 1992. Nature. 355: 359-61. PMID: 1309942
2. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.  |  Heyman, RA., et al. 1992. Cell. 68: 397-406. PMID: 1310260
3. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.  |  Yang, N., et al. 1991. Proc Natl Acad Sci U S A. 88: 3559-63. PMID: 1850832
4. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily.  |  Koelle, MR., et al. 1991. Cell. 67: 59-77. PMID: 1913820
5. A functional retinoic acid receptor encoded by the gene on human chromosome 12.  |  Ishikawa, T., et al. 1990. Mol Endocrinol. 4: 837-44. PMID: 2172793
6. PPARγ phase separates with RXRα at PPREs to regulate target gene expression.  |  Li, Z., et al. 2022. Cell Discov. 8: 37. PMID: 35473936
7. Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer.  |  Zhao, M., et al. 2022. Proc Natl Acad Sci U S A. 119: e2206737119. PMID: 36442107
8. Ligand Screening System for the RXRα Heterodimer Using the Fluorescence RXR Agonist CU-6PMN.  |  Kawasaki, M., et al. 2023. ACS Med Chem Lett. 14: 291-296. PMID: 36923911
9. lncRNA RMST suppresses the progression of colorectal cancer by competitively binding to miR-27a-3p/RXRα axis and inactivating Wnt signaling pathway.  |  Chen, S., et al. 2023. Acta Biochim Biophys Sin (Shanghai). 55: 726-735. PMID: 37246895
10. Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation.  |  Ye, X., et al. 2023. BMC Biol. 21: 197. PMID: 37735649
11. Binding of Per- and Polyfluoroalkyl Substances (PFAS) to the PPARγ/RXRα-DNA Complex.  |  Almeida, NMS., et al. 2023. J Chem Inf Model. 63: 7423-7443. PMID: 37990410
12. Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.  |  Bhat, MK., et al. 1994. Proc Natl Acad Sci U S A. 91: 7927-31. PMID: 8058736

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RXRα Antibody (H-10) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-RXRα Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RXRα Antibody (H-10) Specifications

Alternate Product Name: RXRA

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-29

Epitope Target: RXRα

Epitope Species: human

Product Reactivity/Detection: RXRα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for RXRα Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred RXRα/β/γ antibody is RXRα/β/γ Antibody (F-1): sc-46659.