RUNX3 Antibody (B-9): sc-376543
- RUNX3 Antibody (B-9) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 191-240 mapping within an internal region of RUNX3 of human origin
- recommended for detection of RUNX3 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-376543 X, 200 µg/0.1 ml)
- See RUNX3 (R3-5G4): sc-101553 for RUNX3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for RUNX3 Antibody (B-9) for WB applications. These reagents are now offered in bundles with RUNX3 Antibody (B-9) (see ordering information below).
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RUNX3 Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects RUNX3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RUNX3 is a crucial member of the Runt-related transcription factor family, which plays a significant role in regulating gene expression related to cellular differentiation and cell cycle progression. RUNX3 is predominantly expressed in hematopoietic cells, including myeloid and B-cell lines, as well as in the spleen, highlighting RUNX3′s importance in the immune system. RUNX3 is involved in the growth and differentiation of gastric epithelial cells, positioning RUNX3 as a potential tumor suppressor in gastric cancer. RUNX3′s function is particularly critical because hypermethylation of the RUNX3 gene can lead to inactivation, which has been associated with the development of gastric cancer. Detection of hypermethylation within the RUNX3 CpG island can serve as a valuable biomarker for diagnosing gastric cancer and assessing patient risk, making anti-RUNX3 antibody (B-9) an essential tool for researchers studying cancer biology and epigenetic regulation.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RUNX3 Antibody (B-9) References:
- Runx3 in Immunity, Inflammation and Cancer. | Lotem, J., et al. 2017. Adv Exp Med Biol. 962: 369-393. PMID: 28299669
- RUNX3-Mediated Immune Cell Development and Maturation. | Boto, P., et al. 2018. Crit Rev Immunol. 38: 63-78. PMID: 29717663
- The correlation between Runx3 and bronchial asthma. | Yu, Y., et al. 2018. Clin Chim Acta. 487: 75-79. PMID: 30218658
- Two faces of RUNX3 in myeloid transformation. | Yokomizo-Nakano, T. and Sashida, G. 2021. Exp Hematol. 97: 14-20. PMID: 33600870
- RUNX3 in Stem Cell and Cancer Biology. | Chuang, LSH., et al. 2023. Cells. 12: PMID: 36766749
- Role of RUNX3 in Restriction Point Regulation. | Lee, JW., et al. 2023. Cells. 12: PMID: 36899846
- RUNX3 Meets the Ubiquitin-Proteasome System in Cancer. | Toska, A., et al. 2023. Cells. 12: PMID: 36899853
- p53 Deficiency-Dependent Oncogenicity of Runx3. | Ito, K., et al. 2023. Cells. 12: PMID: 37190031
- Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a. | Zitti, B., et al. 2023. Immunity. 56: 1285-1302.e7. PMID: 37269830
- Endothelial RUNX3 controls LSEC dysfunction and angiocrine LRG1 signaling to prevent liver fibrosis. | Ojha, U., et al. 2024. Hepatology.. PMID: 39042837
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RUNX3 Antibody (B-9) | sc-376543 | 200 µg/ml | $322.00 | |||
RUNX3 Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-540596 | 200 µg Ab; 10 µg BP | $361.00 | |||
RUNX3 Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-542231 | 200 µg Ab; 20 µg BP | $361.00 | |||
RUNX3 Antibody (B-9) X | sc-376543 X | 200 µg/0.1 ml | $322.00 |