RUNX1 Antibody (DW71): sc-101146

RUNX1 Antibody (DW71) is a mouse monoclonal IgG2b kappa light chain antibody that detects RUNX1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RUNX1 (DW71) antibody is available in a non-conjugated form, allowing for versatile applications in various experimental settings. RUNX1, also known as AML-1, PEBP2αB, or CBFA2, is a crucial member of the Runt-related transcription factor family, which includes RUNX2 and RUNX3. RUNX1 plays a vital role in hematopoiesis, the process of blood cell formation, and is frequently implicated in human leukemia due to chromosomal translocations that disrupt function by fusing with other transcription factors and corepressor molecules. Additionally, RUNX1 is essential for sensory neuron diversification, promoting axonal growth and being selectively expressed in neural crest-derived TrkA+ sensory neurons, facilitating TrkA transactivation in migratory neural crest cells. RUNX1′s ability to regulate gene expression through alternative splicing results in several isoforms, each potentially contributing to diverse biological functions. Understanding RUNX1′s role in these processes is critical for elucidating involvement in both normal development and disease states, making anti-RUNX1 antibody (DW71) an invaluable tool for researchers studying these pathways.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RUNX1 Antibody (DW71) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-RUNX1 Antibody (DW71) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RUNX1 Antibody (DW71) Specifications

Alternate Product Name: RUNX1

Product Clone Name: DW71

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 210-311

Epitope Target: RUNX1

Epitope Species: human

Product Reactivity/Detection: a broad range of RUNX1 isoforms

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for RUNX1 Antibody (DW71): N/A

The preferred RUNX1 antibody is RUNX1 Antibody (A-2): sc-365644.