RT1-Ac Antibody (3H2686): sc-71975

RT1-Ac Antibody (3H2686) is a mouse monoclonal IgG2a antibody that detects RT1-Ac in mouse and rat samples through immunofluorescence (IF) and flow cytometry (FCM) applications. RT1-Ac monoclonal antibody (3H2686) recognizes a crucial component of the rat class I major histocompatibility complex (MHC I) molecules, specifically representing haplotype c of the RT1-A antigens. These molecules play a vital role in the immune response by presenting nonself peptides on the cell surface, which are essential for recognition by cytotoxic T-lymphocytes (CTLs). The structure of RT1-Ac consists of two polypeptide chains: an alpha or heavy chain and beta-2-microglobulin, a non-covalently associated protein. This structural arrangement allows for the binding of antigenic peptides, typically 8-10 residues in length, within a specialized peptide binding groove. The ability of RT1-Ac to effectively present these peptides is critical for the activation of CTLs, which are key players in the adaptive immune response, enabling the body to target and eliminate infected or malignant cells. Anti-RT1-Ac antibody (3H2686) serves as an invaluable tool for researchers studying immune responses in rodent models.

The preferred RT1-Ac antibody is RT1-Ac Antibody (OX27): sc-53076.