Rsk-3 Antibody (3C4C8): sc-517283

Rsk-3 Antibody (3C4C8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rsk-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Rsk-3 (3C4C8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rsk-3 is a member of the ribosomal S6 kinase family, which plays a crucial role in cellular signaling pathways activated by receptor tyrosine kinases. One of the key functions of Rsk-3 is involvement in the regulation of cell growth and survival, particularly in response to mitogenic signals. This regulation is vital for normal cellular function and development, as dysregulation of Rsk-3 has been implicated in various diseases, including cancer. Dual kinase catalytic domains allow Rsk-3 to phosphorylate a range of substrates, thereby influencing multiple downstream signaling pathways. Understanding Rsk-3′s role in these processes is essential for developing targeted therapies in conditions where these pathways are disrupted.

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Rsk-3 Antibody (3C4C8) References:

1. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.  |  Dümmler, BA., et al. 2005. J Biol Chem. 280: 13304-14. PMID: 15632195
2. Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.  |  Kozma, SC., et al. 1990. Proc Natl Acad Sci U S A. 87: 7365-9. PMID: 1699226
3. Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.  |  Banerjee, P., et al. 1990. Proc Natl Acad Sci U S A. 87: 8550-4. PMID: 2236064
4. Identification of mitogen-responsive ribosomal protein S6 kinase pp90rsk, a homolog of Xenopus S6 kinase II, in chicken embryo fibroblasts.  |  Sweet, LJ., et al. 1990. Mol Cell Biol. 10: 2413-7. PMID: 2325657
5. RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome.  |  Passariello, CL., et al. 2016. J Mol Cell Cardiol. 93: 98-105. PMID: 26940993
6. Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.  |  Alcorta, DA., et al. 1989. Mol Cell Biol. 9: 3850-9. PMID: 2779569
7. RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells.  |  Wang, M., et al. 2020. J Anat. 237: 29-47. PMID: 32162697
8. RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells.  |  Zhang, S., et al. 2020. Theranostics. 10: 6915-6927. PMID: 32550912
9. MYSM1 induces apoptosis and sensitizes TNBC cells to cisplatin via RSK3-phospho-BAD pathway.  |  Guan, X., et al. 2022. Cell Death Discov. 8: 84. PMID: 35217648
10. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.  |  Zhao, Y., et al. 1995. Mol Cell Biol. 15: 4353-63. PMID: 7623830
11. Divergent functional roles for p90rsk kinase domains.  |  Bjørbaek, C., et al. 1995. J Biol Chem. 270: 18848-52. PMID: 7642538
12. Human rsk isoforms: cloning and characterization of tissue-specific expression.  |  Moller, DE., et al. 1994. Am J Physiol. 266: C351-9. PMID: 8141249

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rsk-3 Antibody (3C4C8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Rsk-3 Antibody (3C4C8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rsk-3 Antibody (3C4C8) Specifications

Alternate Product Name: Rsk-3

Product Clone Name: 3C4C8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 415-734

Epitope Target: Rsk-3

Epitope Species: human

Product Reactivity/Detection: Rsk-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Rsk-3 Antibody (3C4C8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin