ROD1 Antibody (F-30): sc-100845

ROD1 Antibody (F-30) is a mouse monoclonal IgG1 kappa light chain antibody that detects ROD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ROD1 (F-30) antibody is available as the non-conjugated form. ROD1 plays a crucial role in the regulation of differentiation, a fundamental process necessary for proper formation and function of multicellular organisms. ROD1 functions as an RNA binding protein containing four repeats of typical RNA binding domains, essential for RNA molecule interaction and gene expression regulation. ROD1 shows high expression in adult and embryonic hematopoietic cells and organs, indicating a significant role in hematopoiesis. ROD1 overexpression effectively blocks human leukemia cell differentiation without impacting proliferative capacity, highlighting a critical function in maintaining balance between cell proliferation and differentiation in mammalian systems. ROD1′s ability to modulate these processes makes ROD1 a vital target for research into differentiation pathways and potential therapeutic interventions in hematological malignancies.

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ROD1 Antibody (F-30) References:

1. Isolation of a mammalian homologue of a fission yeast differentiation regulator.  |  Yamamoto, H., et al. 1999. Mol Cell Biol. 19: 3829-41. PMID: 10207106
2. PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance.  |  Andoh, T., et al. 2002. FEBS Lett. 525: 131-4. PMID: 12163175
3. Mating pheromone-like diffusible factor released by Schizosaccharomyces pombe.  |  Fukui, Y., et al. 1986. EMBO J. 5: 1991-3. PMID: 16453698
4. Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question.  |  Horvitz, HR. and Herskowitz, I. 1992. Cell. 68: 237-55. PMID: 1733500
5. Regulator of differentiation 1 (ROD1) binds to the amphipathic C-terminal peptide of thrombospondin-4 and is involved in its mitogenic activity.  |  Sadvakassova, G., et al. 2009. J Cell Physiol. 220: 672-9. PMID: 19441079
6. A new function of ROD1 in nonsense-mediated mRNA decay.  |  Brazão, TF., et al. 2012. FEBS Lett. 586: 1101-10. PMID: 22575643
7. Overexpression of ROD1 inhibits invasion of breast cancer cells by suppressing the translocation of β-catenin into the nucleus.  |  Zhou, Y., et al. 2018. Oncol Lett. 16: 2645-2653. PMID: 30013660
8. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.  |  Chen, J., et al. 2018. Cell Res. 28: 981-995. PMID: 30143796
9. YTHDC1 promotes the malignant progression of gastric cancer by promoting ROD1 translocation to the nucleus.  |  Dong, D., et al. 2024. Cell Biol Toxicol. 40: 19. PMID: 38573528
10. A canonical protein complex controls immune homeostasis and multipathogen resistance.  |  Wu, Y., et al. 2024. Science. 386: 1405-1412. PMID: 39509474
11. ROD1, a novel gene conferring multiple resistance phenotypes in Saccharomyces cerevisiae.  |  Wu, AL., et al. 1996. J Biol Chem. 271: 2914-20. PMID: 8621680

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ROD1 Antibody (F-30) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-ROD1 Antibody (F-30) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ROD1 Antibody (F-30) Specifications

Alternate Product Name: ROD1

Product Clone Name: F-30

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 16-115

Epitope Target: ROD1

Epitope Species: human

Product Reactivity/Detection: ROD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for ROD1 Antibody (F-30): N/A

The preferred ROD1 antibody is ROD1 Antibody (C-1): sc-398105.