RNH1 Antibody (G-1): sc-166485

RNH1 Antibody (G-1) is a mouse monoclonal IgG1 antibody that detects RNH1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). RNH1, known as the placental ribonuclease inhibitor, is a crucial 460-amino acid protein characterized by a high content of leucine and cysteine residues, which contributes to structural stability and functional versatility. RNH1 plays a vital role in regulating mRNA turnover by binding to various intracellular and extracellular ribonucleases, effectively keeping them in a latent form. Notably, RNH1 also inhibits angiogenesis by reversibly binding to angiogenin, a member of the RNase A superfamily, which is essential for tumor growth and metastasis. By modulating angiogenesis, RNH1 may have significant implications in cancer gene therapy, making RNH1 a valuable target for therapeutic interventions. Anti-RNH1 antibody (G-1) is an essential tool for researchers investigating the intricate roles of ribonuclease inhibitors in cellular processes and their potential impact on cancer biology.

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RNH1 Antibody (G-1) References:

1. PP011. Increased placental expression of angiogenin inhibitor (Ribonuclease inhibitor), a novel gene in pre-eclampsia.  |  Karanam, VL., et al. 2012. Pregnancy Hypertens. 2: 245-6. PMID: 26105334
2. Engineered human angiogenin mutations in the placental ribonuclease inhibitor complex for anticancer therapy: Insights from enhanced sampling simulations.  |  Cong, X., et al. 2016. Protein Sci. 25: 1451-60. PMID: 27110669
3. Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.  |  Chennupati, V., et al. 2018. J Clin Invest. 128: 1597-1614. PMID: 29408805
4. Regulation of IRE1 RNase activity by the Ribonuclease inhibitor 1 (RNH1).  |  Tavernier, Q., et al. 2018. Cell Cycle. 17: 1901-1916. PMID: 30109813
5. Angiogenin (ANG)-Ribonuclease Inhibitor (RNH1) System in Protein Synthesis and Disease.  |  Sarangdhar, MA. and Allam, R. 2021. Int J Mol Sci. 22: PMID: 33525475
6. Ribonuclease inhibitor 1 (RNH1) deficiency cause congenital cataracts and global developmental delay with infection-induced psychomotor regression and anemia.  |  Hedberg-Oldfors, C., et al. 2023. Eur J Hum Genet. 31: 887-894. PMID: 36935417
7. Human molecular genetics sheds light on the physiological significance of ribonuclease inhibitor (RNH1).  |  Sarangdhar, MA., et al. 2023. Eur J Hum Genet. 31: 856-858. PMID: 37085604
8. Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy.  |  Shashi, V., et al. 2023. Genet Med. 25: 100897. PMID: 37191094
9. Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation.  |  Stillinovic, M., et al. 2024. Sci Adv. 10: eadl0320. PMID: 38820160
10. Ribonuclease Inhibitor 1 (RNH1) Regulates Sperm tsRNA Generation for Paternal Inheritance through Interacting with Angiogenin in the Caput Epididymis.  |  Ma, Z., et al. 2024. Antioxidants (Basel). 13: PMID: 39199264

The preferred RNH1 antibody is RNH1 Antibody (A-9): sc-365783.