RNH1 Antibody (C-10): sc-271725
- RNH1 Antibody (C-10) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 157-456 mapping at the C-terminus of RNH1 of mouse origin
- Anti-RNH1 Antibody (C-10) is recommended for detection of RNH1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-RNH1 Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RNH1 Antibody (C-10) for WB and IHC(P) applications. These reagents are now offered in bundles with RNH1 Antibody (C-10) (see ordering information below).
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SEE ALSO...
RNH1 Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects RNH1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RNH1 antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RNH1, known as the placental ribonuclease inhibitor, is a crucial acidic protein composed of 460 amino acids, characterized by a high content of leucine and cysteine residues. RNH1 plays a vital role in cellular processes by binding to and inhibiting a wide range of ribonucleases, thereby regulating mRNA turnover and maintaining RNA stability within the cytosol. RNH1′s ability to bind angiogenin, a member of the RNaseA superfamily, is particularly significant as RNH1 inhibits angiogenesis, a process essential for tumor growth and metastasis. RNH1 may have important implications in cancer gene therapy, making RNH1 a valuable target for research and therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RNH1 Antibody (C-10) References:
- Kinetic characterization of two active mutants of placental ribonuclease inhibitor that lack internal repeats. | Lee, FS. and Vallee, BL. 1990. Biochemistry. 29: 6633-8. PMID: 2397204
- An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract. | Spencer, JD., et al. 2014. Kidney Int. 85: 1179-91. PMID: 24107847
- Tryptophan fluorescence as a probe of placental ribonuclease inhibitor binding to angiogenin. | Lee, FS., et al. 1989. Biochemistry. 28: 219-24. PMID: 2706245
- Binding of placental ribonuclease inhibitor to the active site of angiogenin. | Lee, FS. and Vallee, BL. 1989. Biochemistry. 28: 3556-61. PMID: 2742853
- Primary structure of human placental ribonuclease inhibitor. | Lee, FS., et al. 1988. Biochemistry. 27: 8545-53. PMID: 3219362
- A concise review on the role of BDNF-AS in human disorders. | Ghafouri-Fard, S., et al. 2021. Biomed Pharmacother. 142: 112051. PMID: 34426254
- IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis. | Zhang, Z., et al. 2021. BMC Med. 19: 282. PMID: 34781942
- Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases. | Akiyama, Y., et al. 2022. Front Mol Biosci. 9: 791094. PMID: 35300117
- Exploring prognostic DNA methylation genes in bladder cancer: a comprehensive analysis. | Zhang, J., et al. 2024. Discov Oncol. 15: 331. PMID: 39095590
- Disruption of the Crithidia fasciculata RNH1 gene results in the loss of two active forms of ribonuclease H. | Ray, DS. and Hines, JC. 1995. Nucleic Acids Res. 23: 2526-30. PMID: 7630731
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNH1 Antibody (C-10) | sc-271725 | 200 µg/ml | $322.00 | |||
RNH1 Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-522041 | 200 µg Ab, 40 µg BP | $361.00 | |||
RNH1 Antibody (C-10): m-IgG1 BP-HRP Bundle | sc-533516 | 200 µg Ab; 20 µg BP | $361.00 | |||
RNH1 Antibody (C-10) AC | sc-271725 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RNH1 Antibody (C-10) HRP | sc-271725 HRP | 200 µg/ml | $322.00 | |||
RNH1 Antibody (C-10) FITC | sc-271725 FITC | 200 µg/ml | $336.00 | |||
RNH1 Antibody (C-10) PE | sc-271725 PE | 200 µg/ml | $349.00 | |||
RNH1 Antibody (C-10) Alexa Fluor® 488 | sc-271725 AF488 | 200 µg/ml | $364.00 | |||
RNH1 Antibody (C-10) Alexa Fluor® 546 | sc-271725 AF546 | 200 µg/ml | $364.00 | |||
RNH1 Antibody (C-10) Alexa Fluor® 594 | sc-271725 AF594 | 200 µg/ml | $364.00 | |||
RNH1 Antibody (C-10) Alexa Fluor® 647 | sc-271725 AF647 | 200 µg/ml | $364.00 | |||
RNH1 Antibody (C-10) Alexa Fluor® 680 | sc-271725 AF680 | 200 µg/ml | $364.00 | |||
RNH1 Antibody (C-10) Alexa Fluor® 790 | sc-271725 AF790 | 200 µg/ml | $364.00 |