RNF167 Antibody (E-9): sc-515405
- RNF167 Antibody (E-9) is a mouse monoclonal IgG2b κ RNF167 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 309-328 near the C-terminus of RNF167 of human origin
- RNF167 Antibody (E-9) is recommended for detection of RNF167 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-RNF167 Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RNF167 Antibody (E-9) for WB applications. These reagents are now offered in bundles with RNF167 Antibody (E-9) (see ordering information below).
RNF167 Antibody (E-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects RNF167 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RNF167 (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RNF167, also known as RING finger protein 167 or RING105, features a RING-type zinc finger domain and a protease-associated domain, which are crucial for functioning as an E3 ubiquitin-protein ligase. RNF167 is primarily localized to the endomembrane system of cytoplasmic membranes and is strongly expressed in the kidney and liver, where RNF167 plays a significant role in regulating protein degradation and cellular processes. The presence of the RING-type zinc finger motif allows RNF167 to facilitate protein-protein and protein-DNA interactions, which are essential for various cellular functions, including growth regulation during the G1/S transition of the cell cycle. By accepting ubiquitin from specific E2 enzymes and transferring ubiquitin to substrates such as ORCTL2, RNF167 is integral to maintaining cellular homeostasis and responding to stress signals, making RNF167 a vital component in the regulation of numerous biological pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RNF167 Antibody (E-9) References:
- Large-scale cDNA transfection screening for genes related to cancer development and progression. | Wan, D., et al. 2004. Proc Natl Acad Sci U S A. 101: 15724-9. PMID: 15498874
- Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase. | Kotoshiba, S., et al. 2005. J Biol Chem. 280: 17694-700. PMID: 15746103
- Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. | Yamada, HY. and Gorbsky, GJ. 2006. Oncogene. 25: 1330-9. PMID: 16314844
- A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors. | Nakakuki, M., et al. 2007. FEBS J. 274: 4440-52. PMID: 17662109
- Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells. | Lee, JG. and Kay, EP. 2008. Invest Ophthalmol Vis Sci. 49: 189-96. PMID: 18172092
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNF167 Antibody (E-9) | sc-515405 | 200 µg/ml | $322.00 | |||
RNF167 Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-525024 | 200 µg Ab, 40 µg BP | $361.00 | |||
RNF167 Antibody (E-9): m-IgG2b BP-HRP Bundle | sc-549208 | 200 µg Ab; 10 µg BP | $361.00 | |||
RNF167 Antibody (E-9) AC | sc-515405 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RNF167 Antibody (E-9) HRP | sc-515405 HRP | 200 µg/ml | $322.00 | |||
RNF167 Antibody (E-9) FITC | sc-515405 FITC | 200 µg/ml | $336.00 | |||
RNF167 Antibody (E-9) PE | sc-515405 PE | 200 µg/ml | $349.00 | |||
RNF167 Antibody (E-9) Alexa Fluor® 488 | sc-515405 AF488 | 200 µg/ml | $364.00 | |||
RNF167 Antibody (E-9) Alexa Fluor® 546 | sc-515405 AF546 | 200 µg/ml | $364.00 | |||
RNF167 Antibody (E-9) Alexa Fluor® 594 | sc-515405 AF594 | 200 µg/ml | $364.00 | |||
RNF167 Antibody (E-9) Alexa Fluor® 647 | sc-515405 AF647 | 200 µg/ml | $364.00 | |||
RNF167 Antibody (E-9) Alexa Fluor® 680 | sc-515405 AF680 | 200 µg/ml | $364.00 | |||
RNF167 Antibody (E-9) Alexa Fluor® 790 | sc-515405 AF790 | 200 µg/ml | $364.00 | |||
RNF167 (E-9) Neutralizing Peptide | sc-515405 P | 100 µg/0.5 ml | $69.00 |