RNF152 Antibody (F-6): sc-398391
- RNF152 Antibody (F-6) is a mouse monoclonal IgG2b κ RNF152 antibody provided at 200 µg/ml
- raised against amino acids 65-130 mapping within an internal region of RNF152 of human origin
- RNF152 Antibody (F-6) is recommended for detection of RNF152 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-RNF152 Antibody (F-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RNF152 Antibody (F-6) for WB applications. These reagents are now offered in bundles with RNF152 Antibody (F-6) (see ordering information below).
RNF152 Antibody (F-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects RNF152 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RNF152 (F-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RNF152, also known as ring finger protein 152, is a 203 amino acid protein characterized by the presence of a RING-type zinc finger motif, which is crucial for its role in the ubiquitination pathway of protein degradation. This motif consists of a conserved cysteine-rich domain capable of binding two zinc ions, a feature that is essential for RNF152′s structural integrity and function. The ubiquitination process mediated by RNF152 is vital for regulating various cellular processes, including the degradation of misfolded proteins and the modulation of signaling pathways, thereby maintaining cellular homeostasis. The gene encoding RNF152 is located on human chromosome 18, a region associated with several genetic disorders, including Trisomy 18 and various cancers, highlighting RNF152′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RNF152 Antibody (F-6) References:
- Characterisation of a 19-year-old 'long-term survivor' with Edwards syndrome. | Petek, E., et al. 2003. Genet Couns. 14: 239-44. PMID: 12872820
- A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. | Raghavan, SC., et al. 2004. Nature. 428: 88-93. PMID: 14999286
- Chromosome 18 aberrations and epilepsy: a review. | Grosso, S., et al. 2005. Am J Med Genet A. 134A: 88-94. PMID: 15690352
- Heterogeneity of mutations in the ferrochelatase gene in Italian patients with erythropoietic protoporphyria. | Aurizi, C., et al. 2007. Mol Genet Metab. 90: 402-7. PMID: 17196862
- Hereditary hemorrhagic telangiectasia. | Kamal, AH. and Prakash, UB. 2007. Mayo Clin Proc. 82: 1364. PMID: 17976356
- Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism. | Shovlin, CL., et al. 2007. Thromb Haemost. 98: 1031-9. PMID: 18000608
- Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. | Deng, L., et al. 2019. Cell Res. 29: 136-150. PMID: 30514904
- Ring finger protein 152 inhibits colorectal cancer cell growth and is a novel prognostic biomarker. | Cui, X., et al. 2018. Am J Transl Res. 10: 3701-3712. PMID: 30662620
- A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. | Zhang, W., et al. 2021. PLoS Biol. 19: e3001361. PMID: 34297722
- The RING finger. A novel protein sequence motif related to the zinc finger. | Freemont, PS. 1993. Ann N Y Acad Sci. 684: 174-92. PMID: 8317827
- Linkage of Niemann-Pick disease type C to human chromosome 18. | Carstea, ED., et al. 1993. Proc Natl Acad Sci U S A. 90: 2002-4. PMID: 8446622
- The RING finger domain: a recent example of a sequence-structure family. | Borden, KL. and Freemont, PS. 1996. Curr Opin Struct Biol. 6: 395-401. PMID: 8804826
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNF152 Antibody (F-6) | sc-398391 | 200 µg/ml | $316.00 | |||
RNF152 Antibody (F-6): m-IgGκ BP-HRP Bundle | sc-524321 | 200 µg Ab, 40 µg BP | $354.00 | |||
RNF152 Antibody (F-6): m-IgG2b BP-HRP Bundle | sc-549159 | 200 µg Ab; 10 µg BP | $354.00 | |||
RNF152 Antibody (F-6) AC | sc-398391 AC | 500 µg/ml, 25% agarose | $416.00 | |||
RNF152 Antibody (F-6) HRP | sc-398391 HRP | 200 µg/ml | $316.00 | |||
RNF152 Antibody (F-6) FITC | sc-398391 FITC | 200 µg/ml | $330.00 | |||
RNF152 Antibody (F-6) PE | sc-398391 PE | 200 µg/ml | $343.00 | |||
RNF152 Antibody (F-6) Alexa Fluor® 488 | sc-398391 AF488 | 200 µg/ml | $357.00 | |||
RNF152 Antibody (F-6) Alexa Fluor® 546 | sc-398391 AF546 | 200 µg/ml | $357.00 | |||
RNF152 Antibody (F-6) Alexa Fluor® 594 | sc-398391 AF594 | 200 µg/ml | $357.00 | |||
RNF152 Antibody (F-6) Alexa Fluor® 647 | sc-398391 AF647 | 200 µg/ml | $357.00 | |||
RNF152 Antibody (F-6) Alexa Fluor® 680 | sc-398391 AF680 | 200 µg/ml | $357.00 | |||
RNF152 Antibody (F-6) Alexa Fluor® 790 | sc-398391 AF790 | 200 µg/ml | $357.00 |