RNF152 Antibody (F-4): sc-398407

RNF152 Antibody (F-4) is a mouse monoclonal IgG1 antibody that detects RNF152 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RNF152, also known as ring finger protein 152, is a 203 amino acid protein characterized by the presence of a RING-type zinc finger motif, which is crucial for its role in the ubiquitination pathway of protein degradation. This motif consists of a conserved cysteine-rich domain capable of binding two zinc ions, enabling RNF152 to interact with various substrates involved in cellular degradation processes. Proper functioning of RNF152 helps regulate protein turnover, thereby maintaining cellular homeostasis and preventing the accumulation of damaged or misfolded proteins. The gene encoding RNF152 is located on human chromosome 18, a region associated with several genetic disorders, including Trisomy 18 and various cancers. RNF152′s ability to mediate protein degradation highlights its importance in cellular regulation and potential implications in disease mechanisms, making anti-RNF152 antibody (F-4) an essential tool for researchers studying protein dynamics and related pathologies.

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RNF152 Antibody (F-4) References:

1. Calcium prevents tumorigenesis in a mouse model of colorectal cancer.  |  Wang, JL., et al. 2011. PLoS One. 6: e22566. PMID: 21857934
2. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.  |  Wu, Y., et al. 2018. PLoS One. 13: e0190407. PMID: 29300766
3. Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells.  |  Ferreira da Silva, J., et al. 2019. Sci Rep. 9: 15751. PMID: 31673055
4. RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization.  |  Xiong, MG., et al. 2020. EMBO Rep. 21: e48860. PMID: 31930677
5. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.  |  Okamoto, T., et al. 2020. Int J Mol Sci. 21: PMID: 32486221
6. Identification of genes related to intramuscular fat independent of backfat thickness in Duroc pigs using single-step genome-wide association.  |  Zhang, Z., et al. 2021. Anim Genet. 52: 108-113. PMID: 33073401
7. Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration.  |  Choi, MR., et al. 2020. Biol Sex Differ. 11: 65. PMID: 33228793
8. RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.  |  Zhu, D., et al. 2023. Am J Pathol. 193: 1603-1617. PMID: 37717980
9. Genetic and Environmental Factors in Autoimmune Thyroid Disease: Exploring Associations with Selenium Levels and Novel Loci in a Latvian Cohort.  |  Upmale-Engela, S., et al. 2024. Curr Issues Mol Biol. 46: 2553-2565. PMID: 38534778
10. Cross cell-type systems genetics reveals the influence of eQTL at multiple points in the developmental trajectory of mouse neural progenitor cells.  |  Aydin, S., et al. 2025. bioRxiv.. PMID: 39896448

The preferred RNF152 antibody is RNF152 Antibody (F-6): sc-398391.