RNase Z1 Antibody (347.1): sc-101113
- RNase Z1 Antibody (347.1) is a mouse monoclonal IgG2a κ provided at 50 µg/0.5 ml
- raised against recombinant RNase Z1 of human origin
- recommended for detection of RNase Z1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RNase Z1 Antibody (347.1). This work is in progress.
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RNase Z1 Antibody (347.1) is a mouse monoclonal IgG2a antibody that detects RNase Z1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). RNase Z1, also known as ELAC1 or D29, is a crucial 363 amino acid nuclear protein that belongs to the RNase Z family of RNA-processing enzymes, primarily expressed in the lung, brain, placenta, heart, liver, kidney, and pancreas. RNase Z1 functions as a zinc phosphodiesterase, playing a vital role in tRNA maturation by removing 3′-trailer segments from precursor tRNA, which is essential for the proper functioning of tRNA in protein synthesis. RNase Z1 exhibits various zinc-dependent RNA processing activities, including the generation of 3′ termini on tRNA, endonucleolytic cleavage of RNA, and the removal of extra 3′ nucleotides from unprocessed tRNA. Defects in the gene encoding RNase Z1 have been implicated in the pathogenesis of prostate cancer, highlighting RNase Z1′s potential role in carcinogenesis and making RNase Z1 a significant target for further research in cancer biology. anti-RNase Z1 antibody (347.1) is an invaluable tool for researchers investigating the intricate mechanisms of RNA processing and its implications in health and disease.
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RNase Z1 Antibody (347.1) References:
- Assigning a function to a conserved group of proteins: the tRNA 3'-processing enzymes. | Schiffer, S., et al. 2002. EMBO J. 21: 2769-77. PMID: 12032089
- Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z. | Chen, Y., et al. 2005. BMC Mol Biol. 6: 12. PMID: 15892892
- Effect of RNase on Zein Synthesis in Endosperms of brittle-2opaque-2 Maize Double Mutant. | Lee, L. and Tsai, CY. 1984. Plant Physiol. 76: 79-83. PMID: 16663828
- Toll-like receptor 7 selective synthetic oligoribonucleotide agonists: synthesis and structure-activity relationship studies. | Lan, T., et al. 2009. J Med Chem. 52: 6871-9. PMID: 19824640
- Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities. | Mitra, M., et al. 2015. Retrovirology. 12: 3. PMID: 25614027
- A five-variable signature predicts radioresistance and prognosis in nasopharyngeal carcinoma patients receiving radical radiotherapy. | Yi, HM., et al. 2016. Tumour Biol. 37: 2941-9. PMID: 26409455
- ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control. | Yip, MCJ., et al. 2020. Cell Rep. 30: 2106-2114.e5. PMID: 32075755
- Transcription from the proximal promoter of ELAC1, a gene for tRNA repair, is upregulated by interferons. | Seki, M., et al. 2021. Biochem Biophys Res Commun. 585: 162-168. PMID: 34808499
- Interaction of the opaque-2 gene with starch-forming mutant genes on the synthesis of zein in maize endosperm. | Tsai, CY., et al. 1978. Biochem Genet. 16: 883-96. PMID: 743193
- Bis(acetato)bis(1-methyl-4,5-diphenylimidazole)copper(II): preparation, characterization, crystal structure, DNA strand breakage and cytogenetic effect. | Raptopoulou, CP., et al. 1998. J Inorg Biochem. 71: 15-27. PMID: 9755488
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNase Z1 Antibody (347.1) | sc-101113 | 50 µg/0.5 ml | $316.00 |