RIP140 Antibody (2656C6a): sc-81370

RIP140 Antibody (2656C6a) is a mouse monoclonal IgG1 kappa light chain antibody that detects RIP140 of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-RIP140 antibody (2656C6a) is available in a non-conjugated form, providing researchers with a versatile tool for studying this critical protein. RIP140 plays a vital role as a transcriptional coactivator and corepressor, interacting with the activation function 2 (AF2) domain of nuclear receptors, which are essential for regulating gene expression in response to steroid hormones, thyroid hormones, and retinoic acids. RIP140 (2656C6a) antibody enables researchers to study how RIP140 modulates transcription in various physiological processes, including metabolism, development, and cellular differentiation. RIP140′s interactions with other transcriptional coactivators and corepressors, such as GRIP1, SRC-1, and RAC3, highlight its importance in the intricate network of gene regulation. Notably, RIP140′s involvement in the transcriptional regulation of hormone-responsive elements makes RIP140 a significant player in conditions such as hormone-dependent cancers, where expression levels can influence tumor progression. RIP140 monoclonal antibody (2656C6a) helps researchers gain deeper insights into the functional dynamics of RIP140 and its implications in health and disease.

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RIP140 Antibody (2656C6a) References:

1. Role of the RIP140 corepressor in ovulation and adipose biology.  |  Steel, JH., et al. 2005. J Endocrinol. 185: 1-9. PMID: 15817822
2. Role of nuclear receptor corepressor RIP140 in metabolic syndrome.  |  Rosell, M., et al. 2011. Biochim Biophys Acta. 1812: 919-28. PMID: 21193034
3. RIP140 as a novel therapeutic target in the treatment of atherosclerosis.  |  Karasawa, T. and Takahashi, M. 2015. J Mol Cell Cardiol. 81: 136-8. PMID: 25701715
4. Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia.  |  Lapierre, M., et al. 2015. J Hematol Oncol. 8: 20. PMID: 25879677
5. RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure.  |  Yamamoto, T., et al. 2023. J Clin Invest. 133: PMID: 36927960
6. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.  |  Oñate, SA., et al. 1995. Science. 270: 1354-7. PMID: 7481822
7. The nuclear hormone receptor gene superfamily.  |  Ribeiro, RC., et al. 1995. Annu Rev Med. 46: 443-53. PMID: 7598477
8. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.  |  Hong, H., et al. 1996. Proc Natl Acad Sci U S A. 93: 4948-52. PMID: 8643509
9. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.  |  Torchia, J., et al. 1997. Nature. 387: 677-84. PMID: 9192892
10. RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.  |  Li, H., et al. 1997. Proc Natl Acad Sci U S A. 94: 8479-84. PMID: 9238002
11. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.  |  Anzick, SL., et al. 1997. Science. 277: 965-8. PMID: 9252329

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RIP140 Antibody (2656C6a) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-RIP140 Antibody (2656C6a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RIP140 Antibody (2656C6a) Specifications

Alternate Product Name: RIP140

Product Clone Name: 2656C6a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: RIP140

Epitope Species: human

Product Reactivity/Detection: RIP140

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for RIP140 Antibody (2656C6a): N/A

The preferred RIP140 antibody is RIP140 Antibody (F-2): sc-518071.