RIP/Rab Antibody (H-2): sc-166651

RIP/Rab Antibody (H-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects RIP/Rab protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RIP/Rab monoclonal antibody (H-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RIP/Rab protein, consisting of 562 amino acids, plays a crucial role in the HIV-1 life cycle by acting as a cellular cofactor that binds to the Rev activation domain, which is essential for the nuclear export and translation of incompletely spliced HIV-1 mRNAs. This interaction is vital because, without RIP/Rab, these late viral RNAs remain trapped in the nucleus, preventing the production of necessary viral structural proteins. The ability of RIP/Rab to facilitate the Rev response underscores RIP/Rab′s importance in HIV-1 replication, making RIP/Rab a significant target for research into therapeutic interventions against HIV.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RIP/Rab Antibody (H-2) References:

1. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs.  |  Fischer, U., et al. 1995. Cell. 82: 475-83. PMID: 7543368
2. Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.  |  Bogerd, HP., et al. 1995. Cell. 82: 485-94. PMID: 7634337
3. A human nucleoporin-like protein that specifically interacts with HIV Rev.  |  Fritz, CC., et al. 1995. Nature. 376: 530-3. PMID: 7637788
4. Regulation of human retroviral latency by the NF-kappa B/I kappa B family: inhibition of human immunodeficiency virus replication by I kappa B through a Rev-dependent mechanism.  |  Wu, BY., et al. 1995. Proc Natl Acad Sci U S A. 92: 1480-4. PMID: 7878004
5. Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein.  |  Kubota, S., et al. 1996. J Virol. 70: 1282-7. PMID: 8551596
6. Analysis of trans-dominant mutants of the HIV type 1 Rev protein for their ability to inhibit Rev function, HIV type 1 replication, and their use as anti-HIV gene therapeutics.  |  Ragheb, JA., et al. 1995. AIDS Res Hum Retroviruses. 11: 1343-53. PMID: 8573391
7. Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A.  |  Bevec, D., et al. 1996. Science. 271: 1858-60. PMID: 8596953

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RIP/Rab Antibody (H-2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-RIP/Rab Antibody (H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RIP/Rab Antibody (H-2) Specifications

Alternate Product Name: RIP/Rab

Product Clone Name: H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 263-562

Epitope Target: RIP/Rab

Epitope Species: human

Product Reactivity/Detection: RIP/Rab

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for RIP/Rab Antibody (H-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin