Rictor Antibody (1G11): sc-81538

Rictor Antibody (1G11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rictor in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). Anti-Rictor antibody (1G11) is available in a non-conjugated form, providing researchers with a versatile tool for studying this critical protein. Rictor, also known as the rapamycin-insensitive companion of FRAP, plays a vital role in cellular signaling pathways, particularly in the regulation of cell growth and metabolism. Rictor (1G11) antibody targets a key component of the mTOR complex 2 (mTORC2), which is essential for the phosphorylation of Akt/PKB at Ser473, a modification that is crucial for Akt′s full activation and subsequent role in promoting cell survival and growth. Proper functioning of Rictor is significant because dysregulation of this pathway is often implicated in various cancers and metabolic disorders. Rictor interacts with several other proteins, including mTOR and various members of the AGC kinase family, which further underscores its importance in cellular signaling networks. Rictor monoclonal antibody (1G11) enables researchers to gain insights into the complex mechanisms of cell growth regulation and potential therapeutic targets for diseases associated with mTOR signaling dysregulation.

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Rictor Antibody (1G11) References:

1. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.  |  Ohara, O., et al. 2002. DNA Res. 9: 47-57. PMID: 12056414
2. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.  |  Sarbassov, DD., et al. 2004. Curr Biol. 14: 1296-302. PMID: 15268862
3. Large-scale characterization of HeLa cell nuclear phosphoproteins.  |  Beausoleil, SA., et al. 2004. Proc Natl Acad Sci U S A. 101: 12130-5. PMID: 15302935
4. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.  |  Jacinto, E., et al. 2004. Nat Cell Biol. 6: 1122-8. PMID: 15467718
5. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.  |  Sarbassov, DD., et al. 2005. Science. 307: 1098-101. PMID: 15718470
6. Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.  |  Ali, SM. and Sabatini, DM. 2005. J Biol Chem. 280: 19445-8. PMID: 15809305
7. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.  |  Hresko, RC. and Mueckler, M. 2005. J Biol Chem. 280: 40406-16. PMID: 16221682
8. Lipotoxic Hepatocyte-Derived Exosomal MicroRNA 192-5p Activates Macrophages Through Rictor/Akt/Forkhead Box Transcription Factor O1 Signaling in Nonalcoholic Fatty Liver Disease.  |  Liu, XL., et al. 2020. Hepatology. 72: 454-469. PMID: 31782176
9. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.  |  Wang, C., et al. 2024. Oncogene. 43: 328-340. PMID: 38040804
10. Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesis.  |  Wang, C., et al. 2023. J Transl Med. 21: 919. PMID: 38110956
11. RICTOR/mTORC2 downregulation in BRAFV600E melanoma cells promotes resistance to BRAF/MEK inhibition.  |  Ponzone, L., et al. 2024. Mol Cancer. 23: 105. PMID: 38755661
12. Rictor/mTORC2 signalling contributes to renal vascular endothelial-to-mesenchymal transition and renal allograft interstitial fibrosis by regulating BNIP3-mediated mitophagy.  |  Feng, D., et al. 2024. Clin Transl Med. 14: e1686. PMID: 38769658

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rictor Antibody (1G11) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-Rictor Antibody (1G11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rictor Antibody (1G11) Specifications

Alternate Product Name: Rictor

Product Clone Name: 1G11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Rictor

Epitope Species: human

Product Reactivity/Detection: Rictor

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, PEG and sucrose

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for Rictor Antibody (1G11): N/A

The preferred Rictor antibody is Rictor Antibody (H-11): sc-271081.