Ribosomal Protein LP0 Antibody (1B4): sc-293260

Ribosomal Protein LP0 Antibody (1B4) is a mouse monoclonal IgG2a kappa light chain antibody that detects Ribosomal Protein LP0 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Ribosomal Protein LP0 antibody (1B4) is available as the non-conjugated format. Ribosomal Protein LP0, also known as RPLP0, P0, L10E, or RPP0, is a crucial component of the 60S ribosomal subunit, consisting of 317 amino acids and functioning as a neutral phosphoprotein. Ribosomal Protein LP0 plays a vital role in ribosome assembly and translation initiation, forming a pentameric complex with Ribosomal Proteins LP1 and LP2, which is essential for proper ribosome function in protein synthesis. Ribosomal Protein LP0′s interaction with other ribosomal proteins ensures structural integrity and functionality of the ribosome, fundamental for cellular growth and proliferation. Notably, overexpression of Ribosomal Protein LP0 has been linked to liver and breast cancer, highlighting its potential role in tumorigenesis and making Ribosomal Protein LP0 a target of interest in cancer research. Additionally, like many mammalian ribosomal proteins, Ribosomal Protein LP0 is represented by multiple processed pseudogenes scattered throughout the genome, indicating its evolutionary significance and complexity.

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Ribosomal Protein LP0 Antibody (1B4) References:

1. Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B.  |  Chan, SH., et al. 2001. Eur J Biochem. 268: 2107-12. PMID: 11277934
2. The subcellular distribution of the human ribosomal 'stalk' components: P1, P2 and P0 proteins.  |  Tchórzewski, M., et al. 2003. Int J Biochem Cell Biol. 35: 203-11. PMID: 12479870
3. Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.  |  Mazumder, B., et al. 2003. Cell. 115: 187-98. PMID: 14567916
4. The molecular mechanics of eukaryotic translation.  |  Kapp, LD. and Lorsch, JR. 2004. Annu Rev Biochem. 73: 657-704. PMID: 15189156
5. Baculovirus-mediated expression and isolation of human ribosomal phosphoprotein P0 carrying a GST-tag in a functional state.  |  Abo, Y., et al. 2004. Biochem Biophys Res Commun. 322: 814-9. PMID: 15336536
6. Characteristics and clustering of human ribosomal protein genes.  |  Ishii, K., et al. 2006. BMC Genomics. 7: 37. PMID: 16504170
7. Characterization of the full-length cDNA, chromosomal localization, and polymorphism of the porcine RPLP0 gene.  |  Wu, X., et al. 2007. J Genet Genomics. 34: 104-8. PMID: 17469782
8. Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells.  |  Chang, TW., et al. 2008. Oncogene. 27: 332-8. PMID: 17621266
9. The Ribosomal Protein RPLP0 Mediates PLAAT4-induced Cell Cycle Arrest and Cell Apoptosis.  |  Wang, CH., et al. 2019. Cell Biochem Biophys. 77: 253-260. PMID: 31131438
10. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.  |  Rich, BE. and Steitz, JA. 1987. Mol Cell Biol. 7: 4065-74. PMID: 3323886
11. miR-4731-5p Enhances Apoptosis and Alleviates Epithelial-Mesenchymal Transition through Targeting RPLP0 in Non-Small-Cell Lung Cancer.  |  Chang, C. and Xu, M. 2022. J Oncol. 2022: 3793318. PMID: 35342398
12. Exploring the function and prognostic value of RPLP0, RPLP1 and RPLP2 expression in lung adenocarcinoma.  |  Xu, C., et al. 2024. J Mol Histol. 55: 1079-1091. PMID: 39207634

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ribosomal Protein LP0 Antibody (1B4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Ribosomal Protein LP0 Antibody (1B4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ribosomal Protein LP0 Antibody (1B4) Specifications

Alternate Product Name: Ribosomal Protein LP0

Product Clone Name: 1B4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-317

Epitope Target: Ribosomal Protein LP0

Epitope Species: human

Product Reactivity/Detection: Ribosomal Protein LP0

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Ribosomal Protein LP0 Antibody (1B4): N/A