Ribosomal Protein L14 Antibody (A-10): sc-518234

Ribosomal Protein L14 Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody specific for an epitope mapping between amino acids 94-116 of Ribosomal Protein L14 of human origin, in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ribosomal Protein L14 monoclonal antibody (A-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Ribosomal Protein L14, also known as L14, RL14, eL14, hRL14, CTG-B33, and CAG-ISL-7, is a crucial component of the 60S ribosomal subunit, consisting of 213 amino acids. Ribosomal Protein L14 plays a vital role in protein synthesis, which is essential for cellular function and growth. Located in the cytoplasm, Ribosomal Protein L14 belongs to the L14e family of ribosomal proteins and features a basic region-leucine zipper (bZIP)-like domain along with a polymorphic polyalanine tract. The polyalanine tract is particularly significant as involvement in transcription regulation highlights the multifaceted roles beyond structural contributions to the ribosome. Like many ribosomal proteins, Ribosomal Protein L14 is associated with multiple processed pseudogenes dispersed throughout the genome, reflecting evolutionary history and functional importance in cellular biology. These features make anti-Ribosomal Protein L14 antibody (A-10) a versatile and reliable tool for studying ribosomal biology and related cellular processes.

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Ribosomal Protein L14 Antibody (A-10) References:

1. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.  |  Uechi, T., et al. 2001. Genomics. 72: 223-30. PMID: 11401437
2. Autoantibody against ribosomal protein L14 in patients with systemic lupus erythematosus.  |  Hasegawa, H., et al. 2002. Clin Exp Rheumatol. 20: 139-44. PMID: 12051391
3. Silencing the Drosophila ribosomal protein L14 gene using targeted RNA interference causes distinct somatic anomalies.  |  Enerly, E., et al. 2003. Gene. 320: 41-8. PMID: 14597387
4. Alteration of RPL14 in squamous cell carcinomas and preneoplastic lesions of the esophagus.  |  Huang, XP., et al. 2006. Gene. 366: 161-8. PMID: 16316724
5. Polymorphic CUG repeats in human mRNAs and their effects on gene expression.  |  Tian, B., et al. 2005. RNA Biol. 2: 149-56. PMID: 17114933
6. Human/eukaryotic ribosomal protein L14 (RPL14/eL14) overexpression represses proliferation, migration, invasion and EMT process in nasopharyngeal carcinoma.  |  Zhang, Z., et al. 2021. Bioengineered. 12: 2175-2186. PMID: 34057029
7. Mitochondrial Ribosomal Protein L14 Promotes Cell Growth and Invasion by Modulating Reactive Oxygen Species in Thyroid Cancer.  |  Kim, HJ., et al. 2023. Clin Exp Otorhinolaryngol. 16: 184-197. PMID: 36822197
8. Identification of trinucleotide repeat-containing genes in human pancreatic islets.  |  Aoki, M., et al. 1996. Diabetes. 45: 157-64. PMID: 8549859
9. Primary structure of Drosophila ribosomal protein L14 and identification of conserved protein motifs.  |  Haynes, SR. 1997. DNA Seq. 8: 105-8. PMID: 9522130
10. Distribution of the B33 CTG repeat polymorphism in a subtype of schizophrenia.  |  Bengel, D., et al. 1998. Eur Arch Psychiatry Clin Neurosci. 248: 78-81. PMID: 9684916
11. The binding sites for Xenopus laevis FIII/YY1 in the first exon of L1 and L14 ribosomal protein genes are dispensable for promoter expression.  |  De Rinaldis, E., et al. 1998. Eur J Biochem. 255: 563-9. PMID: 9738894
12. Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): localization to 3p21.3 and loss of heterozygosity in lung and oral cancers.  |  Shriver, SP., et al. 1998. Mutat Res. 406: 9-23. PMID: 9920051

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ribosomal Protein L14 Antibody (A-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Ribosomal Protein L14 Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ribosomal Protein L14 Antibody (A-10) Specifications

Alternate Product Name: Ribosomal Protein L14

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 94-116

Epitope Target: Ribosomal Protein L14

Epitope Species: human

Product Reactivity/Detection: Ribosomal Protein L14

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Ribosomal Protein L14 Antibody (A-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin