rhodopsin Antibody (RET-P1): sc-57433
- rhodopsin Antibody (RET-P1) is a mouse monoclonal IgG1 κ, cited in 16 publications, provided at 200 µg/ml
- raised against a membrane preparation from adult retina of rat origin
- recommended for detection of rhodopsin of mouse, rat and human origin by WB, IP, IF and IHC(P)
- also available conjugated to Alexa Fluor® 647, 200 µg/ml for IF, IHC(P) and FCM
- See rhodopsin (1D4): sc-57432 for rhodopsin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for rhodopsin Antibody (RET-P1). This work is in progress.
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Rhodopsin Antibody (RET-P1) is a mouse monoclonal IgG1 antibody that detects rhodopsin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-rhodopsin antibody (RET-P1) targets a crucial protein located in the photoreceptor cells of the retina, specifically within the outer segments of rod cells, where rhodopsin plays a vital role in the visual phototransduction pathway. Rhodopsin (RET-P1) monoclonal antibody enables research into a protein essential for converting light into electrical signals, enabling vision in low-light conditions. The unique structure of rhodopsin, characterized by seven transmembrane α helices, allows effective interaction with 11-cis-retinal, a chromophore that undergoes isomerization upon photon absorption. This structural change triggers a cascade of biochemical events, ultimately leading to the activation of G proteins and the transmission of visual signals to the brain. Mutations in the rhodopsin gene can result in severe visual impairments, such as retinitis pigmentosa, underscoring rhodopsin′s significance in maintaining normal vision. Anti-rhodopsin antibody (RET-P1) serves as an invaluable tool for researchers studying the mechanisms of vision and the pathophysiology of retinal diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
rhodopsin Antibody (RET-P1) References:
- Rhodopsin and phototransduction. | Hargrave, PA. and McDowell, JH. 1992. Int Rev Cytol. 137B: 49-97. PMID: 1478822
- Structure and activation of rhodopsin. | Zhou, XE., et al. 2012. Acta Pharmacol Sin. 33: 291-9. PMID: 22266727
- Relevance of rhodopsin studies for GPCR activation. | Deupi, X. 2014. Biochim Biophys Acta. 1837: 674-82. PMID: 24041646
- Constitutively active rhodopsin and retinal disease. | Park, PS. 2014. Adv Pharmacol. 70: 1-36. PMID: 24931191
- Rhodopsin targeted transcriptional silencing by DNA-binding. | Botta, S., et al. 2016. Elife. 5: e12242. PMID: 26974343
- Calcium Binding to TAT Rhodopsin. | Sugimoto, T., et al. 2022. J Phys Chem B. 126: 2203-2207. PMID: 35262367
- Gene Therapy for Rhodopsin Mutations. | Lewin, AS. and Smith, WC. 2022. Cold Spring Harb Perspect Med. 12: PMID: 35940643
- Mechanism of Ion Translocation by Na+-Rhodopsin. | Bogachev, AV., et al. 2022. Biochemistry (Mosc). 87: 731-741. PMID: 36171654
- Lysine Ubiquitylation Drives Rhodopsin Protein Turnover. | Chen, APF., et al. 2023. Adv Exp Med Biol. 1415: 493-498. PMID: 37440077
- Mechanism of rhodopsin phosphorylation. | Zhao, X., et al. 1995. Biophys Chem. 56: 183-8. PMID: 7662865
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
rhodopsin Antibody (RET-P1) | sc-57433 | 200 µg/ml | $322.00 | |||
rhodopsin Antibody (RET-P1) Alexa Fluor® 647 | sc-57433 AF647 | 200 µg/ml | $364.00 |