Rho GDIγ Antibody (E-1): sc-393690
- Rho GDIγ Antibody (E-1) is a mouse monoclonal IgG1 κ Rho GDIγ antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-95 mapping at the N-terminus of Rho GDIγ of mouse origin
- Rho GDI gamma Antibody (E-1) is recommended for detection of Rho GDIγ of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Rho GDI gamma Antibody (E-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rho GDIγ Antibody (E-1) for WB applications. These reagents are now offered in bundles with Rho GDIγ Antibody (E-1) (see ordering information below).
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Rho GDIγ Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rho GDI gamma protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Rho GDIγ antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rho GDI gamma protein plays a crucial role in regulating the activity of Rho GTPases, which are pivotal in controlling various cellular processes such as cytoskeletal dynamics, cell migration, and cell cycle progression. By binding to the active GTP-bound form of Rho proteins, Rho GDI gamma inhibits their interaction with downstream effectors, thereby preventing inappropriate signaling that could lead to pathological conditions, including cancer and cardiovascular diseases. Regulation of Rho GTPases by Rho GDI gamma is essential for maintaining cellular homeostasis and ensuring proper cellular responses to external stimuli. Additionally, Rho GDI gamma interacts with several members of the Ras superfamily, including Rho A, Rho B, Rac, and Cdc42, highlighting its importance in a network of signaling pathways that govern cell behavior.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rho GDIγ Antibody (E-1) References:
- Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP. | Garrett, MD., et al. 1991. Biochem J. 276 (Pt 3): 833-6. PMID: 1905930
- The cellular functions of small GTP-binding proteins. | Hall, A. 1990. Science. 249: 635-40. PMID: 2116664
- The GTPase superfamily: a conserved switch for diverse cell functions. | Bourne, HR., et al. 1990. Nature. 348: 125-32. PMID: 2122258
- A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. | Trahey, M. and McCormick, F. 1987. Science. 238: 542-5. PMID: 2821624
- A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors. | Platko, JV., et al. 1995. Proc Natl Acad Sci U S A. 92: 2974-8. PMID: 7708758
- Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. | Scherle, P., et al. 1993. Proc Natl Acad Sci U S A. 90: 7568-72. PMID: 8356058
- Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI. | Dirac-Svejstrup, AB., et al. 1997. EMBO J. 16: 465-72. PMID: 9034329
- RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. | Adra, CN., et al. 1997. Proc Natl Acad Sci U S A. 94: 4279-84. PMID: 9113980
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rho GDIγ Antibody (E-1) | sc-393690 | 200 µg/ml | $322.00 | |||
Rho GDIγ Antibody (E-1): m-IgG Fc BP-HRP Bundle | sc-530541 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rho GDIγ Antibody (E-1): m-IgGκ BP-HRP Bundle | sc-524047 | 200 µg Ab, 40 µg BP | $361.00 | |||
Rho GDIγ Antibody (E-1): m-IgG1 BP-HRP Bundle | sc-544116 | 200 µg Ab; 20 µg BP | $361.00 | |||
Rho GDIγ Antibody (E-1) AC | sc-393690 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Rho GDIγ Antibody (E-1) HRP | sc-393690 HRP | 200 µg/ml | $322.00 | |||
Rho GDIγ Antibody (E-1) FITC | sc-393690 FITC | 200 µg/ml | $336.00 | |||
Rho GDIγ Antibody (E-1) PE | sc-393690 PE | 200 µg/ml | $349.00 | |||
Rho GDIγ Antibody (E-1) Alexa Fluor® 488 | sc-393690 AF488 | 200 µg/ml | $364.00 | |||
Rho GDIγ Antibody (E-1) Alexa Fluor® 546 | sc-393690 AF546 | 200 µg/ml | $364.00 | |||
Rho GDIγ Antibody (E-1) Alexa Fluor® 594 | sc-393690 AF594 | 200 µg/ml | $364.00 | |||
Rho GDIγ Antibody (E-1) Alexa Fluor® 647 | sc-393690 AF647 | 200 µg/ml | $364.00 | |||
Rho GDIγ Antibody (E-1) Alexa Fluor® 680 | sc-393690 AF680 | 200 µg/ml | $364.00 | |||
Rho GDIγ Antibody (E-1) Alexa Fluor® 790 | sc-393690 AF790 | 200 µg/ml | $364.00 |