Rho GDIα Antibody (4A4): sc-130340

Rho GDIα Antibody (4A4) is a mouse monoclonal IgG1 antibody that detects Rho GDIα in mouse, rat, and human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Rho GDIα, also known as ARHGDIA or GDIA1, is a crucial 204 amino acid protein belonging to the Rho GDI family, primarily localized in the cytoplasm. Anti-Rho GDIα antibody (4A4) helps researchers study the protein′s primary function of inhibiting guanosine diphosphate (GDP) dissociation from Rho proteins, which prevents guanosine triphosphate (GTP) binding and subsequent activation of these signaling molecules. This regulatory mechanism is vital for maintaining proper cell signaling pathways that govern processes such as cell proliferation and cytoskeletal organization. Additionally, Rho GDIα can undergo post-translational modification through phosphorylation at Ser 101 by p21-activated kinase (αPAK), which inhibits its activity and may lead to positive feedback regulation of specific Rho GDIα target proteins. Rho GDIα monoclonal antibody (4A4) serves as an essential tool for researchers studying the intricate roles of Rho proteins in cellular functions and their implications in various diseases.

The preferred Ly-GDI/RhoGDI2/ARHGDIB antibody is Ly-GDI/RhoGDI2/ARHGDIB Antibody (G-12): sc-376473.