RhoA Antibody (26C4): sc-418
- RhoA Antibody (26C4) is a mouse monoclonal IgG1 κ RhoA antibody, cited in 1,309 publications, provided at 200 µg/ml
- raised against amino acids 120-150 of Rho A of human origin
- RhoA Antibody (26C4) is recommended for detection of Rho A of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM; also reactive with additional species, including and equine, bovine, porcine and canine
- Anti-RhoA Antibody (26C4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA; and to TRITC for IF, IHC(P) and FCM
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of RhoA (26C4): sc-418.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RhoA Antibody (26C4) for WB and IHC(P) applications. These reagents are now offered in bundles with RhoA Antibody (26C4) (see ordering information below).
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Rho A Antibody (26C4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rho A of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). Rho A (26C4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rho A plays a crucial role in regulating the actin cytoskeleton, which is essential for various cellular processes such as cell shape, motility, and division. Proper function of Rho A is vital for maintaining cellular integrity and facilitating communication between cells, particularly in response to external signals. Dysregulation of Rho A has been implicated in numerous diseases, including cancer, where altered signaling pathways can lead to increased cell migration and invasion. Understanding the interactions and regulatory mechanisms of Rho A is therefore critical for developing targeted therapies in oncology and other fields. Rho A, along with its family members, is characterized by a carboxy-terminal CAAX motif that is essential for post-translational modification and membrane localization, further underscoring the importance of Rho A in cellular dynamics and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RhoA Antibody (26C4) References:
- Post-translational modifications of p21rho proteins. | Adamson, P., et al. 1992. J Biol Chem. 267: 20033-8. PMID: 1400319
- Expression of the ras-related ralA, rho12 and rab genes in adult mouse tissues. | Olofsson, B., et al. 1988. Oncogene. 3: 231-4. PMID: 2457862
- Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins. | Garrett, MD., et al. 1989. J Biol Chem. 264: 10-3. PMID: 2491843
- Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis. | Morris, JD., et al. 1989. Oncogene. 4: 27-31. PMID: 2536916
- Where no Ras has gone before: VPS35 steers N-Ras through the cytosol. | Zhou, M. and Philips, MR. 2019. Small GTPases. 10: 20-25. PMID: 28129035
- K-RAS and N-RAS mutations in testicular germ cell tumors. | Hacioglu, BM., et al. 2017. Bosn J Basic Med Sci. 17: 159-163. PMID: 28426398
- The ras superfamily proteins. | Chardin, P. 1988. Biochimie. 70: 865-8. PMID: 3145021
- ras genes. | Barbacid, M. 1987. Annu Rev Biochem. 56: 779-827. PMID: 3304147
- Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation. | Ferguson, R., et al. 2023. Curr Issues Mol Biol. 45: 2505-2520. PMID: 36975534
- Nucleotide sequence of human rho cDNA clone 12. | Yeramian, P., et al. 1987. Nucleic Acids Res. 15: 1869. PMID: 3822842
- A novel ras-related gene family. | Madaule, P. and Axel, R. 1985. Cell. 41: 31-40. PMID: 3888408
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RhoA Antibody (26C4) | sc-418 | 200 µg/ml | $316.00 | |||
RhoA Antibody (26C4): m-IgG Fc BP-HRP Bundle | sc-528109 | 200 µg Ab; 10 µg BP | $354.00 | |||
RhoA Antibody (26C4): m-IgGκ BP-HRP Bundle | sc-520407 | 200 µg Ab, 40 µg BP | $354.00 | |||
RhoA Antibody (26C4) AC | sc-418 AC | 500 µg/ml, 25% agarose | $416.00 | |||
RhoA Antibody (26C4) HRP | sc-418 HRP | 200 µg/ml | $316.00 | |||
RhoA Antibody (26C4) FITC | sc-418 FITC | 200 µg/ml | $330.00 | |||
RhoA Antibody (26C4) PE | sc-418 PE | 200 µg/ml | $343.00 | |||
RhoA Antibody (26C4) Alexa Fluor® 488 | sc-418 AF488 | 200 µg/ml | $357.00 | |||
RhoA Antibody (26C4) Alexa Fluor® 546 | sc-418 AF546 | 200 µg/ml | $357.00 | |||
RhoA Antibody (26C4) Alexa Fluor® 594 | sc-418 AF594 | 200 µg/ml | $357.00 | |||
RhoA Antibody (26C4) Alexa Fluor® 647 | sc-418 AF647 | 200 µg/ml | $357.00 | |||
RhoA Antibody (26C4) Alexa Fluor® 680 | sc-418 AF680 | 200 µg/ml | $357.00 | |||
RhoA Antibody (26C4) Alexa Fluor® 790 | sc-418 AF790 | 200 µg/ml | $357.00 | |||
RhoA Antibody (26C4) B | sc-418 B | 200 µg/ml | $320.00 | |||
RhoA Antibody (26C4) TRITC | sc-418 TRITC | 200 µg/ml | $320.00 |