Rho 8 Antibody (clone 4): sc-53874
- Rho 8 Antibody (clone 4) is a mouse monoclonal IgG1 κ Rho 8 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against full length recombinant Rho 8 of mouse origin
- Rho 8 Antibody (clone 4) is recommended for detection of Rho 8 of mouse, rat and human origin by WB, IP, IF and ELISA; may cross-react with Rnd1
- Anti-Rho 8 Antibody (clone 4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rho 8 Antibody (clone 4) for WB applications. These reagents are now offered in bundles with Rho 8 Antibody (clone 4) (see ordering information below).
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Rho 8 Antibody (clone 4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rho 8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rho 8 (clone 4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rho 8, a member of the Rho family of small GTPases, plays a crucial role in regulating the actin cytoskeleton, which is essential for various cellular processes such as cell migration, adhesion, and morphology. Proper function of Rho 8 is vital for maintaining cellular integrity and facilitating communication between cells, particularly in development and immune responses. Dysregulation of Rho proteins, including Rho 8, has been implicated in several diseases, including cancer and cardiovascular disorders, highlighting the importance of studying Rho 8 for potential therapeutic interventions. Rho family proteins, including Rho 8, share a conserved structure characterized by a GTP-binding domain, which is critical for their activity and interaction with downstream effectors. Understanding Rho 8 dynamics and interactions can provide insights into molecular mechanisms underlying various pathologies, making anti-Rho 8 antibody (clone 4) an invaluable tool for researchers in the field.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rho 8 Antibody (clone 4) References:
- Post-translational modifications of p21rho proteins. | Adamson, P., et al. 1992. J Biol Chem. 267: 20033-8. PMID: 1400319
- Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes. | Deacu, E., et al. 2004. Cancer Res. 64: 7690-6. PMID: 15520171
- Expression of the ras-related ralA, rho12 and rab genes in adult mouse tissues. | Olofsson, B., et al. 1988. Oncogene. 3: 231-4. PMID: 2457862
- Ionization satellites of the ArHe dimer. | Miteva, T., et al. 2014. J Chem Phys. 140: 204320. PMID: 24880293
- Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins. | Garrett, MD., et al. 1989. J Biol Chem. 264: 10-3. PMID: 2491843
- Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis. | Morris, JD., et al. 1989. Oncogene. 4: 27-31. PMID: 2536916
- Removing the dichroism and retardance artifacts in a collinear backscattering Mueller matrix imaging system. | Chen, Z., et al. 2018. Opt Express. 26: 28288-28301. PMID: 30470003
- The ras superfamily proteins. | Chardin, P. 1988. Biochimie. 70: 865-8. PMID: 3145021
- The Rho GTPase RND3 regulates adipocyte lipolysis. | Dankel, SN., et al. 2019. Metabolism. 101: 153999. PMID: 31672447
- ras genes. | Barbacid, M. 1987. Annu Rev Biochem. 56: 779-827. PMID: 3304147
- Nucleotide sequence of human rho cDNA clone 12. | Yeramian, P., et al. 1987. Nucleic Acids Res. 15: 1869. PMID: 3822842
- A novel ras-related gene family. | Madaule, P. and Axel, R. 1985. Cell. 41: 31-40. PMID: 3888408
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rho 8 Antibody (clone 4) | sc-53874 | 200 µg/ml | $322.00 | |||
Rho 8 Antibody (clone 4): m-IgG Fc BP-HRP Bundle | sc-528583 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rho 8 Antibody (clone 4): m-IgGκ BP-HRP Bundle | sc-520994 | 200 µg Ab, 40 µg BP | $361.00 | |||
Rho 8 Antibody (clone 4) AC | sc-53874 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Rho 8 Antibody (clone 4) HRP | sc-53874 HRP | 200 µg/ml | $322.00 | |||
Rho 8 Antibody (clone 4) FITC | sc-53874 FITC | 200 µg/ml | $336.00 | |||
Rho 8 Antibody (clone 4) PE | sc-53874 PE | 200 µg/ml | $349.00 | |||
Rho 8 Antibody (clone 4) Alexa Fluor® 488 | sc-53874 AF488 | 200 µg/ml | $364.00 | |||
Rho 8 Antibody (clone 4) Alexa Fluor® 546 | sc-53874 AF546 | 200 µg/ml | $364.00 | |||
Rho 8 Antibody (clone 4) Alexa Fluor® 594 | sc-53874 AF594 | 200 µg/ml | $364.00 | |||
Rho 8 Antibody (clone 4) Alexa Fluor® 647 | sc-53874 AF647 | 200 µg/ml | $364.00 | |||
Rho 8 Antibody (clone 4) Alexa Fluor® 680 | sc-53874 AF680 | 200 µg/ml | $364.00 | |||
Rho 8 Antibody (clone 4) Alexa Fluor® 790 | sc-53874 AF790 | 200 µg/ml | $364.00 |