RhCG Antibody (CB-62): sc-100287

RhCG Antibody (CB-62) is a mouse monoclonal IgG2a kappa light chain antibody that detects RhCG protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RhCG antibody (CB-62) is available as a non-conjugated format. RhCG, also known as Rhesus blood group family type C glycoprotein, RHGK (Rh glycoprotein kidney), PDRC2 (tumor-related protein DRC2), or SLC42A3, is a multi-pass membrane protein characterized by three potential N-glycosylation sites and is a member of the Rh subfamily of the ammonium transporter family. RhCG protein is predominantly expressed in the adult and fetal kidney, where RhCG localizes to the apical and/or basolateral cell membrane, depending on the species. RhCG functions as a non-erythroid, bidirectional, electroneutral ammonium transporter, playing a crucial role in renal ammonia metabolism. RhCG protein is found in key regions of the kidney, including the connecting segment, distal convoluted tubule, collecting duct, and initial collecting tubule, which are essential for renal ammonia secretion. Proper functioning of RhCG is vital for maintaining acid-base balance and nitrogen homeostasis in the body, highlighting RhCG′s importance in renal physiology and potential implications in various kidney-related disorders.

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RhCG Antibody (CB-62) References:

1. Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis.  |  Liu, Z., et al. 2000. J Biol Chem. 275: 25641-51. PMID: 10852913
2. A new face of the Rhesus antigen.  |  Heitman, J. and Agre, P. 2000. Nat Genet. 26: 258-9. PMID: 11062455
3. The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast.  |  Marini, AM., et al. 2000. Nat Genet. 26: 341-4. PMID: 11062476
4. Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A.  |  Khademi, S., et al. 2004. Science. 305: 1587-94. PMID: 15361618
5. Hydrophobic cluster analysis and modeling of the human Rh protein three-dimensional structures.  |  Callebaut, I., et al. 2006. Transfus Clin Biol. 13: 70-84. PMID: 16584906
6. Expression of the ammonia transporter, rh C glycoprotein, in normal and neoplastic human kidney.  |  Han, KH., et al. 2006. J Am Soc Nephrol. 17: 2670-9. PMID: 16928804
7. Effect of reduced renal mass on renal ammonia transporter family, Rh C glycoprotein and Rh B glycoprotein, expression.  |  Kim, HY., et al. 2007. Am J Physiol Renal Physiol. 293: F1238-47. PMID: 17652373
8. Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1.  |  Worrell, RT., et al. 2008. Am J Physiol Gastrointest Liver Physiol. 294: G429-40. PMID: 18032481
9. RHCG suppresses cervical cancer progression through inhibiting migration and inducing apoptosis regulated by TGF-β1.  |  Wang, DG., et al. 2018. Biochem Biophys Res Commun. 503: 86-93. PMID: 29852177
10. High RhCG expression predicts poor survival and promotes migration and proliferation of gastric cancer via keeping intracellular alkaline.  |  Chen, P., et al. 2020. Exp Cell Res. 386: 111740. PMID: 31756312
11. Regulation of Rhcg, an ammonia transporter, by aldosterone in the kidney.  |  Eguchi, K., et al. 2021. J Endocrinol. 249: 95-112. PMID: 33705345
12. Expression and clinical significance of RHCG in endometrial cancer.  |  Wang, H., et al. 2024. Histol Histopathol. 39: 611-621. PMID: 37732703

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RhCG Antibody (CB-62) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-RhCG Antibody (CB-62) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RhCG Antibody (CB-62) Specifications

Alternate Product Name: RhCG

Product Clone Name: CB-62

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 418-480

Epitope Target: RhCG

Epitope Species: human

Product Reactivity/Detection: RhCG

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for RhCG Antibody (CB-62): N/A