RHAMM Antibody (H-8): sc-515221
- RHAMM Antibody (H-8) is a mouse monoclonal IgG1 κ RHAMM antibody, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 1-90 mapping at the N-terminus of RHAMM of human origin
- RHAMM Antibody (H-8) is recommended for detection of RHAMM of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-RHAMM Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RHAMM Antibody (H-8) for WB applications. These reagents are now offered in bundles with RHAMM Antibody (H-8) (see ordering information below).
QUICK LINKS
SEE ALSO...
RHAMM Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects RHAMM protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RHAMM (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RHAMM protein, also known as the receptor for hyaluronic acid-mediated motility, plays a crucial role in cell motility and adhesion, which are vital processes in tissue repair and immune response. Located on the cell surface, RHAMM interacts with hyaluronic acid, facilitating cellular signaling and migration, particularly in response to injury or inflammation. RHAMM expression is notably upregulated in malignant lymphoid tissues, linking RHAMM to tumor progression and metastasis formation. Furthermore, RHAMM exists in several isoforms, with variant isoform v4 being implicated in the transformation and metastatic behavior of fibroblasts when over-expressed. RHAMM′s ability to mediate these processes underscores RHAMM′s importance in both normal physiological functions and pathological conditions, making anti-RHAMM antibody (H-8) a valuable tool for researchers studying cancer biology and cell motility.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RHAMM Antibody (H-8) References:
- Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells. | Lokeshwar, VB. and Selzer, MG. 2000. J Biol Chem. 275: 27641-9. PMID: 10882722
- Expression of hyaluronan receptors CD44 and RHAMM in stomach cancers: relevance with tumor progression. | Li, H., et al. 2000. Int J Oncol. 17: 927-32. PMID: 11029494
- CD44 is the principal mediator of hyaluronic-acid-induced melanoma cell proliferation. | Ahrens, T., et al. 2001. J Invest Dermatol. 116: 93-101. PMID: 11168803
- Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility. | Hardwick, C., et al. 1992. J Cell Biol. 117: 1343-50. PMID: 1376732
- Expression and function of a receptor for hyaluronan-mediated motility on normal and malignant B lymphocytes. | Turley, EA., et al. 1993. Blood. 81: 446-53. PMID: 7678518
- Problems with RHAMM: a new link between surface adhesion and oncogenesis? | Hofmann, M., et al. 1998. Cell. 95: 591-2; author reply 592-3. PMID: 9845361
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RHAMM Antibody (H-8) | sc-515221 | 200 µg/ml | $322.00 | |||
RHAMM Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-531316 | 200 µg Ab; 10 µg BP | $361.00 | |||
RHAMM Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-524978 | 200 µg Ab, 40 µg BP | $361.00 | |||
RHAMM Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-552055 | 200 µg Ab; 20 µg BP | $361.00 | |||
RHAMM Antibody (H-8) AC | sc-515221 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RHAMM Antibody (H-8) HRP | sc-515221 HRP | 200 µg/ml | $322.00 | |||
RHAMM Antibody (H-8) FITC | sc-515221 FITC | 200 µg/ml | $336.00 | |||
RHAMM Antibody (H-8) PE | sc-515221 PE | 200 µg/ml | $349.00 | |||
RHAMM Antibody (H-8) Alexa Fluor® 488 | sc-515221 AF488 | 200 µg/ml | $364.00 | |||
RHAMM Antibody (H-8) Alexa Fluor® 546 | sc-515221 AF546 | 200 µg/ml | $364.00 | |||
RHAMM Antibody (H-8) Alexa Fluor® 594 | sc-515221 AF594 | 200 µg/ml | $364.00 | |||
RHAMM Antibody (H-8) Alexa Fluor® 647 | sc-515221 AF647 | 200 µg/ml | $364.00 | |||
RHAMM Antibody (H-8) Alexa Fluor® 680 | sc-515221 AF680 | 200 µg/ml | $364.00 | |||
RHAMM Antibody (H-8) Alexa Fluor® 790 | sc-515221 AF790 | 200 µg/ml | $364.00 |