RGS2 Antibody (BC-43): sc-100761

RGS2 Antibody (BC-43) is a mouse monoclonal IgG2a kappa light chain antibody that detects RGS2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RGS2 (BC-43) antibody is available as a non-conjugated format. RGS2 protein plays a crucial role in regulating G protein signaling pathways, specifically acting as a GTPase-activating protein (GAP) for Gαq, which is vital for modulating various physiological processes, including cardiovascular function and neuronal signaling. By accelerating GTP hydrolysis to GDP, RGS2 effectively inhibits Gαq activity, thereby influencing downstream signaling cascades that affect cell proliferation, differentiation, and response to external stimuli. Precise regulation of G protein signaling by RGS2 is essential for maintaining cellular homeostasis and preventing pathological conditions such as hypertension and heart disease. Through specific interactions with Gα isoforms, RGS2 serves as a key player in cellular signaling networks, making anti-RGS2 antibody (BC-43) an invaluable tool for researchers studying G protein-coupled receptor signaling and its implications in health and disease.

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RGS2 Antibody (BC-43) References:

1. Different beta-subunits determine G-protein interaction with transmembrane receptors.  |  Kleuss, C., et al. 1992. Nature. 358: 424-6. PMID: 1322501
2. Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.  |  Cali, JJ., et al. 1992. J Biol Chem. 267: 24023-7. PMID: 1385432
3. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.  |  von Weizsäcker, E., et al. 1992. Biochem Biophys Res Commun. 183: 350-6. PMID: 1543505
4. Gustducin is a taste-cell-specific G protein closely related to the transducins.  |  McLaughlin, SK., et al. 1992. Nature. 357: 563-9. PMID: 1608467
5. Diversity of G proteins in signal transduction.  |  Simon, MI., et al. 1991. Science. 252: 802-8. PMID: 1902986
6. Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice.  |  Deng, Y., et al. 2022. Mol Metab. 66: 101622. PMID: 36307046
7. Fatty acid metabolism is related to the immune microenvironment changes of gastric cancer and RGS2 is a new tumor biomarker.  |  Yang, S., et al. 2022. Front Immunol. 13: 1065927. PMID: 36591293
8. Long noncoding RNA HITT coordinates with RGS2 to inhibit PD-L1 translation in T cell immunity.  |  Lin, Q., et al. 2023. J Clin Invest. 133: PMID: 37014700
9. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779
10. RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.  |  Watson, N., et al. 1996. Nature. 383: 172-5. PMID: 8774882
11. RGS2/G0S8 is a selective inhibitor of Gqalpha function.  |  Heximer, SP., et al. 1997. Proc Natl Acad Sci U S A. 94: 14389-93. PMID: 9405622
12. RGS9, a GTPase accelerator for phototransduction.  |  He, W., et al. 1998. Neuron. 20: 95-102. PMID: 9459445

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RGS2 Antibody (BC-43) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-RGS2 Antibody (BC-43) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RGS2 Antibody (BC-43) Specifications

Alternate Product Name: RGS2

Product Clone Name: BC-43

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 111-211

Epitope Target: RGS2

Epitope Species: human

Product Reactivity/Detection: RGS2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for RGS2 Antibody (BC-43): N/A