RGS16 Antibody (F-9): sc-398120

RGS16 Antibody (F-9) is a mouse monoclonal IgG2a antibody that detects RGS16 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RGS16 is a member of the regulators of G-protein signaling family, which are crucial for modulating G protein-coupled receptor signaling pathways. RGS16 is predominantly expressed in the retina, where RGS16 plays a vital role in the phototransduction cascade by enhancing the rate of GTP hydrolysis by transducin, thereby regulating the kinetics of signaling. The ability of RGS16 to inhibit G protein-coupled mitogenic signal transduction and the activation of the mitogen-activated protein kinase (MAPK) signaling cascade underscores RGS16′s importance in cellular signaling and potential implications in various physiological processes. The gene encoding RGS16 is located on human chromosome 1q25-q31, highlighting RGS16′s evolutionary conservation and significance across species. Anti-RGS16 antibody (F-9) is an essential tool for researchers investigating the intricate mechanisms of G protein signaling and its impact on cellular functions.

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RGS16 Antibody (F-9) References:

1. RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation.  |  Derrien, A. and Druey, KM. 2001. J Biol Chem. 276: 48532-8. PMID: 11602604
2. Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability.  |  Derrien, A., et al. 2003. J Biol Chem. 278: 16107-16. PMID: 12588871
3. RGS16 inhibits signalling through the G alpha 13-Rho axis.  |  Johnson, EN., et al. 2003. Nat Cell Biol. 5: 1095-103. PMID: 14634662
4. RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling.  |  Liang, G., et al. 2009. J Biol Chem. 284: 21719-27. PMID: 19509421
5. RGS16 is a marker for prognosis in colorectal cancer.  |  Miyoshi, N., et al. 2009. Ann Surg Oncol. 16: 3507-14. PMID: 19760045
6. RGS16 and FosB underexpressed in pancreatic cancer with lymph node metastasis promote tumor progression.  |  Kim, JH., et al. 2010. Tumour Biol. 31: 541-8. PMID: 20571966
7. MiRNA126 - RGS16 - CXCL12 Cascade as a Potential Mechanism of Acute Exercise-Induced Precursor Cell Mobilization.  |  Schmid, M., et al. 2021. Front Physiol. 12: 780666. PMID: 34955891
8. Hypertension is linked to enhanced lymphatic contractile response via RGS16/RhoA/ROCK pathway.  |  Mukohda, M., et al. 2022. Am J Physiol Heart Circ Physiol. 323: H1118-H1129. PMID: 36306212
9. GDF15 negatively regulates RGS16 to impair hepatic lipid metabolism in male mice offspring conceived by in vitro fertilization.  |  Liu, J., et al. 2022. Am J Transl Res. 14: 7535-7551. PMID: 36398249
10. RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor.  |  Zhang, Y., et al. 1999. J Biol Chem. 274: 2851-7. PMID: 9915820

The preferred RGS16 antibody is RGS16 Antibody (A-9): sc-166083.