RGS10 Antibody (A-8): sc-46679

RGS10 Antibody (A-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects RGS10 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RGS10 (A-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RGS10 protein plays a crucial role in regulating G protein signaling pathways, which are essential for transmitting signals from cell surface receptors to intracellular effectors. Specifically, RGS10 acts as a GTPase-activating protein (GAP) for certain G protein alpha subunits, enhancing their ability to hydrolyze GTP to GDP, thereby promoting signaling pathway inactivation. This regulatory function is vital for maintaining cellular homeostasis and ensuring appropriate responses to external stimuli. Dysregulation of RGS10 has been implicated in various diseases, including cancer and neurological disorders, highlighting RGS10′s importance as a potential therapeutic target. With versatile applications and critical role in G protein signaling, anti-RGS10 antibody (A-8) serves as an invaluable tool for researchers studying cellular signaling mechanisms and their implications in health and disease.

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RGS10 Antibody (A-8) References:

1. Different beta-subunits determine G-protein interaction with transmembrane receptors.  |  Kleuss, C., et al. 1992. Nature. 358: 424-6. PMID: 1322501
2. Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.  |  Cali, JJ., et al. 1992. J Biol Chem. 267: 24023-7. PMID: 1385432
3. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.  |  von Weizsäcker, E., et al. 1992. Biochem Biophys Res Commun. 183: 350-6. PMID: 1543505
4. Gustducin is a taste-cell-specific G protein closely related to the transducins.  |  McLaughlin, SK., et al. 1992. Nature. 357: 563-9. PMID: 1608467
5. Diversity of G proteins in signal transduction.  |  Simon, MI., et al. 1991. Science. 252: 802-8. PMID: 1902986
6. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.  |  Merad, M., et al. 2008. Nat Rev Immunol. 8: 935-47. PMID: 19029989
7. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin.  |  Romani, N., et al. 2010. Immunol Rev. 234: 120-41. PMID: 20193016
8. Targeting human langerin promotes HIV-1 specific humoral immune responses.  |  Kervevan, J., et al. 2021. PLoS Pathog. 17: e1009749. PMID: 34324611
9. A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis.  |  Xiao, C., et al. 2022. Front Immunol. 13: 981819. PMID: 36304463
10. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779
11. RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.  |  Watson, N., et al. 1996. Nature. 383: 172-5. PMID: 8774882
12. RGS10 is a selective activator of G alpha i GTPase activity.  |  Hunt, TW., et al. 1996. Nature. 383: 175-7. PMID: 8774883

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RGS10 Antibody (A-8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-RGS10 Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RGS10 Antibody (A-8) Specifications

Alternate Product Name: RGS10

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 15-173

Epitope Target: RGS10

Epitope Species: human

Product Reactivity/Detection: RGS10

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for RGS10 Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin