RELT Antibody (C-6): sc-373942

RELT Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects RELT protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RELT (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RELT protein, also known as receptor expressed in lymphoid tissues or tumor necrosis factor receptor superfamily member 19L (TNFRSF19L), is a transmembrane glycoprotein predominantly expressed in thymus, spleen, testis, colon, skeletal muscle, and peripheral blood lymphocytes. RELT′s unique structure includes two cysteine-rich domains, although one is incomplete, and notably lacks the death domain found in some other tumor necrosis factor receptor family members. This absence of the death domain differentiates RELT from other family members that can bind TRAF adaptor proteins, indicating a distinct signaling pathway. RELT interacts with and becomes phosphorylated by SPAK and OSR1 kinases, which are crucial for the activation of p38 and JNK signaling pathways. These interactions suggest RELT plays a vital role in T-cell activation, as RELT overexpression leads to phosphorylation of c-Jun and ATF2, further implicating RELT in the regulation of important cellular responses.

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RELT Antibody (C-6) References:

1. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB.  |  Sica, GL., et al. 2001. Blood. 97: 2702-7. PMID: 11313261
2. Cytokine-receptor pairing: accelerating discovery of cytokine function.  |  Foster, D., et al. 2004. Nat Rev Drug Discov. 3: 160-70. PMID: 15040579
3. Tumor necrosis factor family ligand-receptor binding.  |  Zhang, G. 2004. Curr Opin Struct Biol. 14: 154-60. PMID: 15093829
4. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.  |  Cusick, JK., et al. 2006. Biochem Biophys Res Commun. 340: 535-43. PMID: 16389068
5. The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation.  |  Polek, TC., et al. 2006. Biochem Biophys Res Commun. 343: 125-34. PMID: 16530727
6. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human.  |  Bossen, C., et al. 2006. J Biol Chem. 281: 13964-71. PMID: 16547002
7. TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis.  |  Polek, TC., et al. 2006. Biochem Biophys Res Commun. 349: 1016-24. PMID: 16950202

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RELT Antibody (C-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-RELT Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RELT Antibody (C-6) Specifications

Alternate Product Name: RELT

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 129-348

Epitope Target: RELT

Epitope Species: human

Product Reactivity/Detection: RELT

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for RELT Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin