RecQL1 Antibody (G-2): sc-166446

RecQL1 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects RecQL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RecQL1 is a member of the RecQ helicase family, which plays a crucial role in maintaining genomic stability by unwinding DNA during replication and repair processes. This function helps prevent DNA damage accumulation that can lead to various genetic disorders and cancers. RecQL1 is primarily located in the nucleus, where RecQL1 interacts with other proteins involved in DNA repair and replication, ensuring cellular processes are carried out accurately and efficiently. RecQL1 has been implicated in the regulation of cell proliferation and apoptosis, making RecQL1 a significant player in cellular responses to stress and damage. The gene encoding RecQL1 is located on chromosome 12p12.1, and while RecQL1′s exact role in genetic disorders is still being explored, RecQL1 expression levels are upregulated in transformed or actively proliferating cells, highlighting RecQL1′s importance in cancer biology. Anti-RecQL1 antibody (G-2) is an essential tool for researchers studying the mechanisms of DNA repair and the implications of RecQ helicases in human health and disease.

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RecQL1 Antibody (G-2) References:

1. RECQL1 DNA repair helicase: a potential therapeutic target and a proliferative marker against ovarian cancer.  |  Sanada, S., et al. 2013. PLoS One. 8: e72820. PMID: 23951333
2. Human RECQL1 participates in telomere maintenance.  |  Popuri, V., et al. 2014. Nucleic Acids Res. 42: 5671-88. PMID: 24623817
3. RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.  |  Futami, K. and Furuichi, Y. 2014. Front Genet. 5: 441. PMID: 25620975
4. Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer.  |  Sun, J., et al. 2015. PLoS Genet. 11: e1005228. PMID: 25945795
5. Clinical implications of germline mutations in breast cancer genes: RECQL.  |  Bowden, AR. and Tischkowitz, M. 2019. Breast Cancer Res Treat. 174: 553-560. PMID: 30610487
6. The RECQL helicase prevents replication fork collapse during replication stress.  |  Benedict, B., et al. 2020. Life Sci Alliance. 3: PMID: 32820027
7. RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.  |  Abu-Libdeh, B., et al. 2022. J Clin Invest. 132: PMID: 35025765
8. Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancer.  |  Gupta, P., et al. 2022. Aging Cell. 21: e13625. PMID: 35582959
9. High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival.  |  Mahmoodi, A., et al. 2022. Front Oncol. 12: 877617. PMID: 35712517
10. Immune infiltration, aggressive pathology, and poor survival outcomes in RECQL helicase deficient breast cancers.  |  Lashen, A., et al. 2024. Neoplasia. 47: 100957. PMID: 38134458

The preferred RecQL1 antibody is RecQL1 Antibody (A-9): sc-166388.