RecQL1 Inhibitors
RecQL1, a key player in DNA repair processes, can be modulated by various chemical inhibitors. Ellipticine directly inhibits RecQL1 by interacting with its DNA binding sites, disrupting its ability to unwind DNA structures and contributing to increased genomic instability. Novobiocin and Ciprofloxacin indirectly influence RecQL1 by targeting DNA gyrase and inhibiting DNA topoisomerase II, respectively. These actions disrupt DNA replication and processing, impacting RecQL1's role in DNA repair and maintenance. NSC 19630 and NSC 617145 are synthetic compounds that directly inhibit RecQL1 helicase activity. Their direct inhibition affects RecQL1's function in unwinding DNA structures, leading to disruptions in DNA repair processes and potentially enhancing sensitivity to DNA-damaging agents.
6-Thioguanine and Teniposide indirectly modulate RecQL1 by incorporating into DNA and inhibiting DNA topoisomerase II, respectively. These actions alter DNA structure and processing, affecting RecQL1's interactions with DNA and contributing to disturbances in DNA repair processes. Monensin, Trifluoperazine, Acridine Orange, Berberine, and Etoposide indirectly influence RecQL1 through various mechanisms such as disrupting ion homeostasis, affecting calcium levels, intercalating with DNA, or modulating cellular metabolism. These indirect modulations impact RecQL1's function in DNA repair processes, potentially leading to disturbances in genomic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $128.00 $380.00 | ||
Novobiocin is a coumarin antibiotic that indirectly influences RecQL1 by targeting DNA gyrase, disrupting DNA replication. This indirect inhibition affects RecQL1's role in DNA unwinding and repair processes, leading to altered genomic stability. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $43.00 | 8 | |
Ciprofloxacin is a fluoroquinolone antibiotic that indirectly modulates RecQL1 by inhibiting DNA topoisomerase II, interfering with DNA processing. This indirect inhibition impacts RecQL1's involvement in DNA repair and maintenance, contributing to altered cellular responses to DNA damage. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Ellipticine is a naturally occurring alkaloid that directly inhibits RecQL1 by interacting with its DNA binding sites. This direct inhibition disrupts RecQL1's ability to unwind DNA structures, hindering its role in DNA repair and contributing to increased genomic instability. | ||||||
MIRA-1 | 72835-26-8 | sc-204087 sc-204087A | 10 mg 50 mg | $118.00 $452.00 | 1 | |
MIRA-1 is a synthetic compound that directly inhibits RecQL1 helicase activity. This direct inhibition impacts RecQL1's role in unwinding DNA structures, leading to disruptions in DNA repair processes and potentially contributing to enhanced sensitivity to DNA-damaging agents. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
6-Thioguanine is a thiopurine derivative that indirectly modulates RecQL1 by incorporating into DNA during replication. This incorporation alters DNA structure and function, affecting RecQL1's interactions with DNA and contributing to disturbances in DNA repair processes. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore antibiotic that indirectly influences RecQL1 by disrupting ion homeostasis and inducing cellular stress. This indirect modulation can impact RecQL1's function in maintaining genomic stability, potentially leading to altered DNA repair responses. | ||||||
Teniposide | 29767-20-2 | sc-204910 sc-204910A | 25 mg 100 mg | $73.00 $235.00 | 6 | |
Teniposide is a podophyllotoxin derivative that indirectly modulates RecQL1 by inhibiting DNA topoisomerase II. This indirect inhibition affects RecQL1's role in DNA processing and repair, contributing to genomic instability and altered cellular responses to DNA damage. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $57.00 $101.00 | 9 | |
Trifluoperazine is an antipsychotic drug that indirectly modulates RecQL1 by disrupting cellular calcium homeostasis. This indirect modulation can impact RecQL1's function in DNA repair processes, potentially leading to disturbances in genomic stability. | ||||||
Acridine Orange solution | 65-61-2 | sc-473594 | 10 ml | $166.00 | 2 | |
Acridine Orange is a DNA intercalating dye that indirectly modulates RecQL1 by affecting DNA structure. This indirect modulation can impact RecQL1's ability to unwind DNA structures, leading to disturbances in DNA repair processes and potentially contributing to increased genomic instability. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is an isoquinoline alkaloid that indirectly modulates RecQL1 by affecting cellular metabolism and energy balance. This indirect modulation can impact RecQL1's function in DNA repair processes, potentially leading to disturbances in genomic stability. | ||||||