RecQL1 Antibody (F-11): sc-166389
- RecQL1 Antibody (F-11) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-110 of RecQL1 of human origin
- recommended for detection of RecQL1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for RecQL1 Antibody (F-11) for WB applications. This reagent is now offered in a bundle with RecQL1 Antibody (F-11) (see ordering information below).
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RecQL1 Antibody (F-11) is a mouse monoclonal IgG2b antibody that detects RecQL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RecQL1 is a member of the RecQ helicase family, which plays a crucial role in maintaining genomic stability by unwinding DNA during replication and repair processes. This function is particularly important as RecQL1 helps prevent the accumulation of DNA damage that can lead to various genetic disorders and cancers. RecQL1 is primarily located in the nucleus, where RecQL1 interacts with other proteins involved in DNA metabolism, ensuring that cellular processes such as replication and repair are carried out efficiently. RecQL1 has been implicated in the regulation of cell cycle progression and apoptosis, highlighting RecQL1′s significance in cellular health and disease. The gene encoding RecQL1 is located on chromosome 12p12.1, and while RecQL1′s exact role in genetic disorders is still being investigated, RecQL1 expression levels are known to be upregulated in response to cellular stress, further underscoring RecQL1′s importance in cellular responses to DNA damage. Anti-RecQL1 antibody (F-11) is an essential tool for researchers studying the mechanisms of DNA repair and the implications of RecQ helicases in human health.
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RecQL1 Antibody (F-11) References:
- Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation. | Wang, W., et al. 2003. Mol Cell Biol. 23: 3527-35. PMID: 12724411
- Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines. | LeRoy, G., et al. 2005. Nucleic Acids Res. 33: 6251-7. PMID: 16260474
- Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase. | Futami, K., et al. 2008. Cancer Sci. 99: 71-80. PMID: 17953710
- Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase IIIalpha. | Otsuki, M., et al. 2008. Biochim Biophys Acta. 1782: 75-81. PMID: 18078829
- Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models. | Futami, K., et al. 2008. Cancer Sci. 99: 1227-36. PMID: 18422747
- Topoisomerase I and RecQL1 function in Epstein-Barr virus lytic reactivation. | Wang, P., et al. 2009. J Virol. 83: 8090-8. PMID: 19494003
- RecQL1 DNA repair helicase: A potential tumor marker and therapeutic target against hepatocellular carcinoma. | Futami, K., et al. 2010. Int J Mol Med. 25: 537-45. PMID: 20198302
- RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma. | Arai, A., et al. 2011. Cancer Res. 71: 4598-607. PMID: 21571861
- RECQL1 DNA repair helicase: a potential therapeutic target and a proliferative marker against ovarian cancer. | Sanada, S., et al. 2013. PLoS One. 8: e72820. PMID: 23951333
- RECQL1 plays an important role in the development of tongue squamous cell carcinoma. | Tao, J., et al. 2014. Cell Physiol Biochem. 33: 1579-90. PMID: 24854846
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RecQL1 Antibody (F-11) | sc-166389 | 200 µg/ml | $316.00 | |||
RecQL1 Antibody (F-11): m-IgG2b BP-HRP Bundle | sc-548516 | 200 µg Ab; 10 µg BP | $354.00 |