RecQL1 Antibody (C-5): sc-271437
- RecQL1 Antibody (C-5) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-35 at the N-terminus of RecQL1 of human origin
- recommended for detection of RecQL1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RecQL1 Antibody (C-5) for WB applications. These reagents are now offered in bundles with RecQL1 Antibody (C-5) (see ordering information below).
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RecQL1 Antibody (C-5) is a mouse monoclonal IgG2a antibody that detects RecQL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RecQL1 is a member of the RecQ helicase family, which plays a crucial role in maintaining genomic stability by unwinding DNA during replication and repair processes. This function is particularly important as RecQL1 helps prevent the accumulation of DNA damage, which can lead to various genetic disorders and cancer. RecQL1 is primarily located in the nucleus, where RecQL1 interacts with other proteins involved in DNA metabolism, ensuring that cellular processes such as replication and repair occur accurately and efficiently. The gene encoding RecQL1 is located on chromosome 12p12.1, and while RecQL1′s exact role in genetic disorders is not fully understood, RecQL1 expression levels are known to be upregulated in actively proliferating cells, highlighting RecQL1′s significance in cellular health and stability. Anti-RecQL1 antibody (C-5) is an essential tool for researchers studying the mechanisms of DNA repair and the implications of RecQ helicases in disease.
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RecQL1 Antibody (C-5) References:
- Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation. | Wang, W., et al. 2003. Mol Cell Biol. 23: 3527-35. PMID: 12724411
- Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models. | Futami, K., et al. 2008. Cancer Sci. 99: 1227-36. PMID: 18422747
- Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma. | Cotton, RT., et al. 2009. HPB (Oxford). 11: 435-44. PMID: 19768149
- RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma. | Arai, A., et al. 2011. Cancer Res. 71: 4598-607. PMID: 21571861
- The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer. | Matsushita, Y., et al. 2014. J Ovarian Res. 7: 107. PMID: 25424877
- Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers. | Arora, A., et al. 2017. Mol Cancer Ther. 16: 239-250. PMID: 27837030
- Human RECQL1 participates in telomere maintenance. | Popuri, V., et al. 2017. Nucleic Acids Res. 45: 2935. PMID: 27923931
- Endogenous Bos taurus RECQL is predominantly monomeric and more active than oligomers. | Liu, NN., et al. 2021. Cell Rep. 36: 109688. PMID: 34496242
- Elevated RECQL1 expression predicts poor prognosis and associates with tumor immune infiltration in low-grade glioma. | Wang, G., et al. 2022. Transl Cancer Res. 11: 1552-1564. PMID: 35836526
- Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. | Seki, T., et al. 1997. Biochem Biophys Res Commun. 234: 48-53. PMID: 9168958
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RecQL1 Antibody (C-5) | sc-271437 | 200 µg/ml | $322.00 | |||
RecQL1 Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-534962 | 200 µg Ab; 40 µg BP | $361.00 | |||
RecQL1 Antibody (C-5): m-IgG2a BP-HRP Bundle | sc-546203 | 200 µg Ab; 10 µg BP | $361.00 | |||
RecQL1 (C-5) Neutralizing Peptide | sc-271437 P | 100 µg/0.5 ml | $69.00 |