RD3 Antibody (A-9): sc-390653
- RD3 Antibody (A-9) is a mouse monoclonal IgG2b κ RD3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 62-87 within an internal region of RD3 of human origin
- RD3 Antibody (A-9) is recommended for detection of RD3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-RD3 Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RD3 Antibody (A-9) for WB applications. These reagents are now offered in bundles with RD3 Antibody (A-9) (see ordering information below).
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RD3 Antibody (A-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects RD3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RD3 (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RD3, also known as retinal degeneration 3 or LCA12, is a crucial 195 amino acid protein predominantly expressed in the retina, where RD3 plays a significant role in the maintenance and development of photoreceptors. RD3 is believed to be part of subnuclear protein complexes that are essential for transcription and splicing processes, which are vital for proper gene expression and cellular function. Mutations in the gene encoding RD3 are linked to Leber congenital amaurosis type 12, a severe genetic disorder that leads to significant visual impairment or blindness in infants due to the loss of retinal photoreceptor function. Understanding RD3 function and interactions is critical for elucidating the underlying mechanisms of retinal diseases and developing potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RD3 Antibody (A-9) References:
- Retinal degeneration mutants in the mouse. | Chang, B., et al. 2002. Vision Res. 42: 517-25. PMID: 11853768
- Progression of phenotype in Leber's congenital amaurosis with a mutation at the LCA5 locus. | Mohamed, MD., et al. 2003. Br J Ophthalmol. 87: 473-5. PMID: 12642313
- Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration. | Friedman, JS., et al. 2006. Am J Hum Genet. 79: 1059-70. PMID: 17186464
- Mutations in LCA5 are an uncommon cause of Leber congenital amaurosis (LCA) type II. | Gerber, S., et al. 2007. Hum Mutat. 28: 1245. PMID: 18000884
- Identification of a novel splice-site mutation in the Lebercilin (LCA5) gene causing Leber congenital amaurosis. | Ramprasad, VL., et al. 2008. Mol Vis. 14: 481-6. PMID: 18334959
- Leber congenital amaurosis: genes, proteins and disease mechanisms. | den Hollander, AI., et al. 2008. Prog Retin Eye Res. 27: 391-419. PMID: 18632300
- Canine RD3 mutation establishes rod-cone dysplasia type 2 (rcd2) as ortholog of human and murine rd3. | Kukekova, AV., et al. 2009. Mamm Genome. 20: 109-23. PMID: 19130129
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RD3 Antibody (A-9) | sc-390653 | 200 µg/ml | $322.00 | |||
RD3 Antibody (A-9): m-IgGκ BP-HRP Bundle | sc-523618 | 200 µg Ab, 40 µg BP | $361.00 | |||
RD3 Antibody (A-9): m-IgG2b BP-HRP Bundle | sc-549129 | 200 µg Ab; 10 µg BP | $361.00 | |||
RD3 Antibody (A-9) AC | sc-390653 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RD3 Antibody (A-9) HRP | sc-390653 HRP | 200 µg/ml | $322.00 | |||
RD3 Antibody (A-9) FITC | sc-390653 FITC | 200 µg/ml | $336.00 | |||
RD3 Antibody (A-9) PE | sc-390653 PE | 200 µg/ml | $349.00 | |||
RD3 Antibody (A-9) Alexa Fluor® 488 | sc-390653 AF488 | 200 µg/ml | $364.00 | |||
RD3 Antibody (A-9) Alexa Fluor® 546 | sc-390653 AF546 | 200 µg/ml | $364.00 | |||
RD3 Antibody (A-9) Alexa Fluor® 594 | sc-390653 AF594 | 200 µg/ml | $364.00 | |||
RD3 Antibody (A-9) Alexa Fluor® 647 | sc-390653 AF647 | 200 µg/ml | $364.00 | |||
RD3 Antibody (A-9) Alexa Fluor® 680 | sc-390653 AF680 | 200 µg/ml | $364.00 | |||
RD3 Antibody (A-9) Alexa Fluor® 790 | sc-390653 AF790 | 200 µg/ml | $364.00 | |||
RD3 (A-9) Neutralizing Peptide | sc-390653 P | 100 µg/0.5 ml | $69.00 |