RCBTB1 Antibody (G-2): sc-377341
- RCBTB1 Antibody (G-2) is a mouse monoclonal IgG1 κ RCBTB1 antibody provided at 200 µg/ml
- raised against amino acids 26-75 mapping near the N-terminus of RCBTB1 of human origin
- RCBTB1 Antibody (G-2) is recommended for detection of RCBTB1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-RCBTB1 Antibody (G-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for RCBTB1 Antibody (G-2) for WB applications. This reagent is now offered in a bundle with RCBTB1 Antibody (G-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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RCBTB1 Antibody (G-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects RCBTB1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RCBTB1 (G-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RCBTB1 protein, also known as regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1, is a 531 amino acid protein that plays a crucial role in cell cycle regulation through chromatin remodeling. RCBTB1 is primarily localized in the nucleus and contains two BTB (POZ) domains and six RCC1 repeats, which are essential for function in transcriptional regulation and chromatin structure control. These domains suggest RCBTB1 may interact with specific proteins involved in chromatin dynamics, thereby influencing gene expression and cellular proliferation. RCBTB1 gene is located on human chromosome 13, a region often deleted in B-cell chronic lymphocytic leukemia, indicating potential role in tumor suppression. Widespread expression of RCBTB1 across various tissues underscores importance in maintaining cellular homeostasis and regulating cell cycle, making anti-RCBTB1 antibody (G-2) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RCBTB1 Antibody (G-2) References:
- Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia. | Mabuchi, H., et al. 2001. Cancer Res. 61: 2870-7. PMID: 11306461
- 13q deletion in chronic lymphocytic leukemia: characterization of E4.5, a novel chromosome condensation regulator-like guanine nucleotide exchange factor. | Solomou, EE., et al. 2003. Leuk Lymphoma. 44: 1579-85. PMID: 14565662
- A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells. | Guo, DF., et al. 2004. J Biol Chem. 279: 21109-20. PMID: 14985364
- The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. | Zollman, S., et al. 1994. Proc Natl Acad Sci U S A. 91: 10717-21. PMID: 7938017
- The POZ domain: a conserved protein-protein interaction motif. | Bardwell, VJ. and Treisman, R. 1994. Genes Dev. 8: 1664-77. PMID: 7958847
- Crystal structure of the BTB domain from PLZF. | Ahmad, KF., et al. 1998. Proc Natl Acad Sci U S A. 95: 12123-8. PMID: 9770450
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RCBTB1 Antibody (G-2) | sc-377341 | 200 µg/ml | $316.00 | |||
RCBTB1 Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-523290 | 200 µg Ab, 40 µg BP | $354.00 | |||
RCBTB1 Antibody (G-2) AC | sc-377341 AC | 500 µg/ml, 25% agarose | $416.00 | |||
RCBTB1 Antibody (G-2) HRP | sc-377341 HRP | 200 µg/ml | $316.00 | |||
RCBTB1 Antibody (G-2) FITC | sc-377341 FITC | 200 µg/ml | $330.00 | |||
RCBTB1 Antibody (G-2) PE | sc-377341 PE | 200 µg/ml | $343.00 | |||
RCBTB1 Antibody (G-2) Alexa Fluor® 488 | sc-377341 AF488 | 200 µg/ml | $357.00 | |||
RCBTB1 Antibody (G-2) Alexa Fluor® 546 | sc-377341 AF546 | 200 µg/ml | $357.00 | |||
RCBTB1 Antibody (G-2) Alexa Fluor® 594 | sc-377341 AF594 | 200 µg/ml | $357.00 | |||
RCBTB1 Antibody (G-2) Alexa Fluor® 647 | sc-377341 AF647 | 200 µg/ml | $357.00 | |||
RCBTB1 Antibody (G-2) Alexa Fluor® 680 | sc-377341 AF680 | 200 µg/ml | $357.00 | |||
RCBTB1 Antibody (G-2) Alexa Fluor® 790 | sc-377341 AF790 | 200 µg/ml | $357.00 |