RCAS1 Antibody (C-10): sc-515559

RCAS1 Antibody (C-10) is a mouse monoclonal IgG2a antibody that detects RCAS1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RCAS1, also known as receptor-binding cancer antigen expressed on SiSo cells or estrogen receptor-binding fragment-associated gene 9, is an estrogen-regulated protein that plays a critical role in immune evasion of tumor cells. RCAS1 is primarily located on the cell membrane and in soluble forms, where RCAS1 interacts with a putative receptor on peripheral lymphocytes, thereby inhibiting T lymphocyte growth and promoting apoptosis. RCAS1 presence in various cancers, including uterine, ovarian, and lung cancers, highlights RCAS1 significance in tumor progression and immune escape mechanisms. High levels of RCAS1 expression are associated with advanced tumor stages and poor prognoses in cancer patients, making RCAS1 a potential biomarker for assessing tumor aggressiveness. The human RCAS1/EBAG9 gene is located on chromosome 8q23, emphasizing RCAS1 relevance in cancer biology and potential therapeutic targeting.

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RCAS1 Antibody (C-10) References:

1. RCAS1 as a tumour progression marker: an independent negative prognostic factor in gallbladder cancer.  |  Oshikiri, T., et al. 2001. Br J Cancer. 85: 1922-7. PMID: 11747335
2. RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung.  |  Oizumi, S., et al. 2002. Oncology. 62: 333-9. PMID: 12138241
3. The expression of RCAS1 and tumor infiltrating lymphocytes in patients with T3 gastric carcinoma.  |  Fukuda, K., et al. 2002. Gastric Cancer. 5: 220-7. PMID: 12491080
4. The level of RCAS1 expression is inversely correlated with the number of vimentin-positive stromal cells in epithelial ovarian cancer.  |  Sonoda, K., et al. 2009. Int J Gynecol Cancer. 19: 838-43. PMID: 19574770
5. Expression of RCAS1 protein in microglia/macrophages accompanying brain tumours. An immunofluorescence study.  |  Adamek, D., et al. 2009. Folia Neuropathol. 47: 240-6. PMID: 19813143
6. Analysis of cell cycle arrest and apoptosis induced by RCAS1.  |  Nishinakagawa, T., et al. 2010. Int J Mol Med. 25: 717-22. PMID: 20372814
7. RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical study.  |  Theocharis, S., et al. 2011. Med Sci Monit. 17: BR228-234. PMID: 21804460
8. Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma.  |  Tanaka, H., et al. 2014. J Transl Med. 12: 112. PMID: 24885040
9. Expression of RCAS1 correlates with urothelial bladder cancer malignancy.  |  Jóźwicki, W., et al. 2015. Int J Mol Sci. 16: 3783-803. PMID: 25674852
10. Cytoplasmic and membranous receptor-binding cancer antigens expressed on SiSo cells (RCAS1) immunoreactivity in epithelial ovarian cancer cells represent differing biological function of RCAS1.  |  Szubert, S., et al. 2019. Folia Histochem Cytobiol. 57: 116-126. PMID: 31388982

The preferred RCAS1 antibody is RCAS1 Antibody (D-9): sc-398052.