RBM10 Antibody (2F12): sc-517062
- RBM10 Antibody (2F12) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against amino acids 123-230 representing partial length RBM10 of human origin
- recommended for detection of RBM10 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RBM10 Antibody (2F12). This work is in progress.
RBM10 Antibody (2F12) is a mouse monoclonal IgG1 antibody that detects RBM10 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). RBM10, also known as GPATC9, MGC997, ZRANB5, GPATCH9, or RNA-binding protein S1-1, is a crucial 930 amino acid nuclear protein characterized by the presence of two RNA recognition motifs, a RanBP2-type zinc finger, a C2H2-type zinc finger, and a G-patch domain. RBM10 plays a significant role in post-transcriptional processing, influencing processes such as apoptosis and cancer proliferation. Notably, RBM10 is involved in the regulation of vascular endothelial growth factor (VEGF) expression, which is vital for angiogenesis and the formation of new blood vessels. The interaction of RBM10 with RNA homopolymers suggests an essential function in modulating gene expression and cellular responses, making RBM10 a key player in various biological processes and a valuable target for research in cancer biology and therapeutic development. Anti-RBM10 antibody (2F12) is an indispensable tool for researchers aiming to explore the intricate roles of RBM10 in cellular mechanisms and disease states.
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RBM10 Antibody (2F12) References:
- RBM10 regulates alternative splicing. | Inoue, A., et al. 2014. FEBS Lett. 588: 942-7. PMID: 24530524
- RBM10 inhibits cell proliferation of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway. | Jin, X., et al. 2019. J Cell Mol Med. 23: 3897-3904. PMID: 30955253
- Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex. | Weigt, M., et al. 2021. Epigenetics Chromatin. 14: 8. PMID: 33468217
- RBM10: Structure, functions, and associated diseases. | Inoue, A. 2021. Gene. 783: 145463. PMID: 33515724
- Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. | Nanjo, S., et al. 2022. J Clin Invest. 132: PMID: 35579943
- RBM10 regulates alternative splicing of lncRNA Neat1 to inhibit the invasion and metastasis of NSCLC. | Cong, S., et al. 2022. Cancer Cell Int. 22: 338. PMID: 36335386
- RBM10 Loss Promotes EGFR-Driven Lung Cancer and Confers Sensitivity to Spliceosome Inhibition. | Bao, Y., et al. 2023. Cancer Res. 83: 1490-1502. PMID: 36853175
- RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated β-catenin signaling in cholangiocarcinoma. | Chang, J., et al. 2024. J Exp Clin Cancer Res. 43: 104. PMID: 38576051
- RBM10 loss induces aberrant splicing of cytoskeletal and extracellular matrix mRNAs and promotes metastatic fitness. | Krishnamoorthy, GP., et al. 2024. bioRxiv.. PMID: 39026820
- Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma. | Machour, FE., et al. 2024. Nat Commun. 15: 6417. PMID: 39080280
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RBM10 Antibody (2F12) | sc-517062 | 100 µg/ml | $316.00 |