RBM10 Activators
RBM10 activators are chemical compounds that modulate the activity of the RNA-binding motif protein 10 (RBM10), which is a protein involved in the regulation of gene expression at the post-transcriptional level. RBM10 itself is part of a larger family of RNA-binding proteins, which play critical roles in various cellular processes such as RNA splicing, editing, transport, and stability. The activators of RBM10 influence the function of this protein, potentially affecting the spliceosomal complex, where RBM10 is known to be an integral component. By interacting with RBM10, these activators can alter the assembly of spliceosomal components, which in turn can impact the splicing of pre-mRNAs into mature mRNAs. This modulation of splicing affects the diversity of the proteome, as alternative splicing can lead to the production of different protein isoforms from a single gene.
The chemical structure and the mechanism of action of RBM10 activators vary depending on the specific compound. Some activators may bind directly to the RBM10 protein, enhancing its natural affinity or altering its conformation to facilitate its interaction with RNA or other components of the spliceosome. Other activators might act indirectly, by influencing the pathways that regulate the expression levels or the localization of RBM10 within the cell. Understanding the precise biochemical interactions between RBM10 activators and their target is crucial for elucidating how these compounds influence RNA processing. As RBM10 is associated with the regulation of gene expression patterns, activators of this protein could have significant effects on the cellular transcriptome and proteome, thereby affecting the functionality of cellular processes. These effects are achieved through complex molecular cascades initiated by the modulation of RBM10 activity, which underscores the intricate nature of cellular regulation mediated by RNA-binding proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Rottlerin enhances RBM10 function by affecting the PI3K/Akt signaling pathway. As a kinase inhibitor, it suppresses Akt activation, releasing RBM10 from Akt-mediated inhibition. This results in increased RBM10 activity in regulating mRNA alternative splicing and processing. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol enhances RBM10 functional activity by modulating the MAPK/ERK signaling pathway. Acting as a MEK inhibitor, it influences the pathway and indirectly upregulates RBM10 expression. This leads to improved RBM10-mediated alternative splicing and mRNA processing. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $105.00 $438.00 $837.00 $1569.00 | 4 | |
Daunorubicin enhances RBM10 activity by impacting the p53 signaling pathway. As a p53 stabilizer, it increases p53 levels, which in turn positively regulates RBM10 expression. This leads to improved RBM10-mediated mRNA processing and alternative splicing. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin enhances RBM10 function through the JNK/p38 MAPK signaling pathway. By inducing DNA damage and activating JNK/p38 MAPK, it positively influences RBM10 expression. This leads to increased RBM10 involvement in mRNA processing and alternative splicing. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin enhances RBM10 functional activity by influencing the TGF-β/Smad signaling pathway. Acting as a TGF-β receptor inhibitor, it prevents Smad2/3 phosphorylation, indirectly upregulating RBM10 expression. This results in improved RBM10-mediated alternative splicing and mRNA processing. | ||||||
Stat3 Inhibitor III, WP1066 | 857064-38-1 | sc-203282 | 10 mg | $132.00 | 72 | |
WP1066 enhances RBM10 activity through the JAK/STAT signaling pathway. As a JAK2 inhibitor, it suppresses STAT3 phosphorylation, positively impacting RBM10 expression. This leads to increased RBM10 functionality in RNA processing and alternative splicing. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide positively influences RBM10 through the NF-κB signaling pathway. As an inhibitor of IκB kinase, it prevents NF-κB activation, indirectly upregulating RBM10 expression. This results in enhanced RBM10 functionality in mRNA processing and alternative splicing. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 enhances RBM10 function by influencing the GSK-3β signaling pathway. As a GSK-3β inhibitor, it stabilizes β-catenin, positively regulating RBM10 expression. This leads to increased RBM10 involvement in alternative splicing and mRNA processing. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol positively influences RBM10 through the HSP90 signaling pathway. As an HSP90 inhibitor, it destabilizes HSP90 client proteins, indirectly upregulating RBM10 expression. This results in enhanced RBM10 functionality in mRNA processing and alternative splicing. | ||||||
15-Deoxy-δ12,14-Prostaglandin J2 | 87893-55-8 | sc-201262 sc-201262A | 1 mg 5 mg | $141.00 $551.00 | 5 | |
15-Deoxy-Δ12,14-prostaglandin enhances RBM10 activity through the COX-2/PGE2 signaling pathway. As a COX-2 inhibitor, it reduces PGE2 levels, positively impacting RBM10 expression. This leads to increased RBM10 involvement in alternative splicing and mRNA processing. | ||||||