RB3 Antibody (B-11): sc-376829
- RB3 Antibody (B-11) is a mouse monoclonal IgG2a κ RB3 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 61-95 within an internal region of RB3 of human origin
- RB3 Antibody (B-11) is recommended for detection of RB3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-RB3 Antibody (B-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RB3 Antibody (B-11) for WB and IHC(P) applications. These reagents are now offered in bundles with RB3 Antibody (B-11) (see ordering information below).
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SEE ALSO...
RB3 Antibody (B-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects RB3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). RB3 Antibody (B-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RB3 (B-11) antibody recognizes Stathmin-like protein B3, which plays a critical role in microtubule dynamics, particularly in brain tissue, where RB3 is involved in microtubule destabilization. This function is essential for various cellular processes, including cell division and intracellular transport, as microtubules are key components of the cytoskeleton that provide structural support and facilitate organelle movement. The unique N-terminal membrane-associated domain and C-terminal Stathmin-like domain of RB3 contribute to tubulin sequestration and microtubule destabilization, which is particularly important for neuronal function and development. RB3 dysregulation has been implicated in several cancers, including breast carcinoma and various leukemias, highlighting RB3′s potential as a biomarker and therapeutic target. Additionally, RB3 expression is associated with neuronal growth-associated protein Stathmin-2, which shares homology with RB3 and is altered in age-related neurodegenerative diseases such as Alzheimer′s disease, further underscoring RB3′s importance in both cancer biology and neurodegeneration.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RB3 Antibody (B-11) References:
- Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain. | Nakao, C., et al. 2004. J Biol Chem. 279: 23014-21. PMID: 15039434
- Stathmin expression modulates migratory properties of GN-11 neurons in vitro. | Giampietro, C., et al. 2005. Endocrinology. 146: 1825-34. PMID: 15625246
- Stathmin prevents the transition from a normal to an endomitotic cell cycle during megakaryocytic differentiation. | Iancu-Rubin, C., et al. 2005. Cell Cycle. 4: 1774-82. PMID: 16258287
- stathmin, a gene enriched in the amygdala, controls both learned and innate fear. | Shumyatsky, GP., et al. 2005. Cell. 123: 697-709. PMID: 16286011
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RB3 Antibody (B-11) | sc-376829 | 200 µg/ml | $322.00 | |||
RB3 Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-523110 | 200 µg Ab, 40 µg BP | $361.00 | |||
RB3 Antibody (B-11): m-IgG2a BP-HRP Bundle | sc-546143 | 200 µg Ab; 10 µg BP | $361.00 | |||
RB3 Antibody (B-11) AC | sc-376829 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RB3 Antibody (B-11) HRP | sc-376829 HRP | 200 µg/ml | $322.00 | |||
RB3 Antibody (B-11) FITC | sc-376829 FITC | 200 µg/ml | $336.00 | |||
RB3 Antibody (B-11) PE | sc-376829 PE | 200 µg/ml | $349.00 | |||
RB3 Antibody (B-11) Alexa Fluor® 488 | sc-376829 AF488 | 200 µg/ml | $364.00 | |||
RB3 Antibody (B-11) Alexa Fluor® 546 | sc-376829 AF546 | 200 µg/ml | $364.00 | |||
RB3 Antibody (B-11) Alexa Fluor® 594 | sc-376829 AF594 | 200 µg/ml | $364.00 | |||
RB3 Antibody (B-11) Alexa Fluor® 647 | sc-376829 AF647 | 200 µg/ml | $364.00 | |||
RB3 Antibody (B-11) Alexa Fluor® 680 | sc-376829 AF680 | 200 µg/ml | $364.00 | |||
RB3 Antibody (B-11) Alexa Fluor® 790 | sc-376829 AF790 | 200 µg/ml | $364.00 | |||
RB3 (B-11) Neutralizing Peptide | sc-376829 P | 100 µg/0.5 ml | $69.00 |