RASSF3 Antibody (E-4): sc-376560
- RASSF3 Antibody (E-4) is a mouse monoclonal IgG1 κ RASSF3 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 21-80 mapping near the N-terminus of RASSF3 of human origin
- RASSF3 Antibody (E-4) is recommended for detection of RASSF3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-RASSF3 Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RASSF3 Antibody (E-4) for WB applications. These reagents are now offered in bundles with RASSF3 Antibody (E-4) (see ordering information below).
QUICK LINKS
RASSF3 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects RASSF3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RASSF3 antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RASSF3 plays a crucial role in cellular signaling pathways, particularly in regulating cell proliferation and apoptosis, making RASSF3 an important factor in cancer biology. Located in the cytoplasm, RASSF3 interacts with Ras protein, which is essential for transmitting signals from cell surface receptors to downstream effectors. This interaction maintains normal cellular functions and prevents uncontrolled cell growth. RASSF3 belongs to the Ras association domain family, which includes RASSF1, RASSF2, and RASSF4, all sharing a conserved Ras association domain and functioning as tumor suppressors. RASSF3 expression in both normal and cancerous tissues highlights RASSF3′s significance in tumorigenesis and potential for targeting in cancer therapies. RASSF3 exists in three isoforms—RASSF3A, RASSF3B, and RASSF3C—resulting from alternative splicing, with RASSF3A being the longest and containing both RA and SARAH domains, while shorter isoforms lack these critical domains.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RASSF3 Antibody (E-4) References:
- RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. | Tommasi, S., et al. 2002. Oncogene. 21: 2713-20. PMID: 11965544
- Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas. | Hesson, L., et al. 2004. Oncogene. 23: 2408-19. PMID: 14743209
- Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR. | Lévy, P., et al. 2004. Mol Cancer. 3: 20. PMID: 15255999
- RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family. | Eckfeld, K., et al. 2004. Cancer Res. 64: 8688-93. PMID: 15574778
- Analysis of ovarian cancer cell lines using array-based comparative genomic hybridization. | Lambros, MB., et al. 2005. J Pathol. 205: 29-40. PMID: 15586366
- CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations. | Hesson, LB., et al. 2005. Oncogene. 24: 3987-94. PMID: 15806169
- The Ras-association domain family (RASSF) members and their role in human tumourigenesis. | van der Weyden, L. and Adams, DJ. 2007. Biochim Biophys Acta. 1776: 58-85. PMID: 17692468
- Induction of apoptosis by NORE1A in a manner dependent on its nuclear export. | Park, SJ., et al. 2008. Biochem Biophys Res Commun. 368: 56-61. PMID: 18211824
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RASSF3 Antibody (E-4) | sc-376560 | 200 µg/ml | $322.00 | |||
RASSF3 Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-523007 | 200 µg Ab, 40 µg BP | $361.00 | |||
RASSF3 Antibody (E-4): m-IgG1 BP-HRP Bundle | sc-533542 | 200 µg Ab; 20 µg BP | $361.00 | |||
RASSF3 Antibody (E-4) AC | sc-376560 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RASSF3 Antibody (E-4) HRP | sc-376560 HRP | 200 µg/ml | $322.00 | |||
RASSF3 Antibody (E-4) FITC | sc-376560 FITC | 200 µg/ml | $336.00 | |||
RASSF3 Antibody (E-4) PE | sc-376560 PE | 200 µg/ml | $349.00 | |||
RASSF3 Antibody (E-4) Alexa Fluor® 488 | sc-376560 AF488 | 200 µg/ml | $364.00 | |||
RASSF3 Antibody (E-4) Alexa Fluor® 546 | sc-376560 AF546 | 200 µg/ml | $364.00 | |||
RASSF3 Antibody (E-4) Alexa Fluor® 594 | sc-376560 AF594 | 200 µg/ml | $364.00 | |||
RASSF3 Antibody (E-4) Alexa Fluor® 647 | sc-376560 AF647 | 200 µg/ml | $364.00 | |||
RASSF3 Antibody (E-4) Alexa Fluor® 680 | sc-376560 AF680 | 200 µg/ml | $364.00 | |||
RASSF3 Antibody (E-4) Alexa Fluor® 790 | sc-376560 AF790 | 200 µg/ml | $364.00 |