RASL11B Antibody (C-3): sc-365425

RASL11B Antibody (C-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects RASL11B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RASL11B (C-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RASL11B, or RAS-like family 11 member B, plays a significant role in cellular signaling pathways, particularly as a Ras-related GTPase. RASL11B shows predominant expression in placenta and primary macrophages, indicating importance in developmental and immune processes. RASL11B stands unique among Ras family counterparts due to absent prenylation sites, which are crucial for membrane localization and function in other Ras proteins. Cytoplasmic localization of RASL11B suggests involvement in mediating responses to extracellular signals, such as those from transforming growth factor beta 1 (TGFβ1), which regulates various developmental processes. RASL11B′s potential role in inflammation, arteriosclerosis, and cancer highlights significance in both normal physiology and disease states, making anti-RASL11B antibody (C-3) a valuable tool for researchers studying these critical biological processes.

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RASL11B Antibody (C-3) References:

1. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9.  |  Piddini, E., et al. 2001. EMBO J. 20: 4076-87. PMID: 11483511
2. Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity.  |  Akiyama, T., et al. 2001. Genes Cells. 6: 987-1001. PMID: 11733036
3. A Ras-like GTPase is involved in hyphal growth guidance in the filamentous fungus Ashbya gossypii.  |  Bauer, Y., et al. 2004. Mol Biol Cell. 15: 4622-32. PMID: 15282338
4. Cloning, genomic organization, and tissue-specific expression of the RASL11B gene.  |  Stolle, K., et al. 2007. Biochim Biophys Acta. 1769: 514-24. PMID: 17628721
5. Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype.  |  Pézeron, G., et al. 2008. PLoS One. 3: e1434. PMID: 18197245
6. Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the development of neuroblastoma.  |  Liu, J. and Li, Y. 2019. Mol Med Rep. 20: 3475-3486. PMID: 31432180
7. RASL11B gene enhances hyaluronic acid-mediated chondrogenic differentiation in human amniotic mesenchymal stem cells via the activation of Sox9/ERK/smad signals.  |  Luo, Y., et al. 2020. Exp Biol Med (Maywood). 245: 1708-1721. PMID: 32878463
8. RIC, a calmodulin-binding Ras-like GTPase.  |  Wes, PD., et al. 1996. EMBO J. 15: 5839-48. PMID: 8918462
9. An effector-like function of Ras GTPase-activating protein predominates in cardiac muscle cells.  |  Abdellatif, M. and Schneider, MD. 1997. J Biol Chem. 272: 525-33. PMID: 8995293
10. Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI).  |  Roa, M., et al. 1997. J Immunol. 159: 2815-23. PMID: 9300704
11. Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes.  |  Reedquist, KA. and Bos, JL. 1998. J Biol Chem. 273: 4944-9. PMID: 9478939
12. The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum.  |  Seastone, DJ., et al. 1999. Mol Biol Cell. 10: 393-406. PMID: 9950684

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RASL11B Antibody (C-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-RASL11B Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RASL11B Antibody (C-3) Specifications

Alternate Product Name: RASL11B

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 217-243

Epitope Target: RASL11B

Epitope Species: human

Product Reactivity/Detection: RASL11B and RASL11A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for RASL11B Antibody (C-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin