RASAL2 Antibody (B-11): sc-390605

RASAL2 Antibody (B-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects RASAL2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RASAL2 antibody (B-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RASAL2, also known as Ras protein activator like 2 or nGAP, plays a crucial role in regulating the Ras signaling pathway, which is vital for cell growth, differentiation, and survival. RASAL2 functions as a GTPase-activating protein (GAP), facilitating the hydrolysis of GTP to GDP, thereby promoting the inactivation of Ras proteins. This regulatory mechanism is essential because aberrations in Ras signaling are often implicated in various cancers, including prostate cancer, where RASAL2 gene is located on chromosome 1 within a susceptibility locus. The presence of a C2 domain, a PH domain, and a Ras-GAP domain in RASAL2 underscores its structural complexity and functional significance in cellular signaling. Alternative splicing of RASAL2 gene results in two transcript variants, which may contribute to diverse regulatory roles in different cellular contexts.

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RASAL2 Antibody (B-11) References:

1. Ras and Rap1: two highly related small GTPases with distinct function.  |  Zwartkruis, FJ. and Bos, JL. 1999. Exp Cell Res. 253: 157-65. PMID: 10579920
2. Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia.  |  von Bergh, AR., et al. 2004. Genes Chromosomes Cancer. 39: 324-34. PMID: 14978793
3. Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations.  |  Walker, SA., et al. 2004. EMBO J. 23: 1749-60. PMID: 15057271
4. CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.  |  Liu, Q., et al. 2005. J Cell Biol. 170: 183-90. PMID: 16009725
5. Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells.  |  Ishikawa, M., et al. 2005. Cancer Sci. 96: 387-93. PMID: 16053509
6. GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins.  |  Kupzig, S., et al. 2006. J Biol Chem. 281: 9891-900. PMID: 16431904
7. The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling.  |  Yarwood, S., et al. 2006. Biochem Soc Trans. 34: 846-50. PMID: 17052212
8. Signaling pathways in cancer and embryonic stem cells.  |  Dreesen, O. and Brivanlou, AH. 2007. Stem Cell Rev. 3: 7-17. PMID: 17873377

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RASAL2 Antibody (B-11) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-RASAL2 Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RASAL2 Antibody (B-11) Specifications

Alternate Product Name: RASAL2

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-48

Epitope Target: RASAL2

Epitope Species: human

Product Reactivity/Detection: RASAL2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for RASAL2 Antibody (B-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin