RARα/Retinoic Acid Receptor α Antibody (1C10): sc-293417

RARα Antibody (1C10) is a mouse monoclonal IgG1 kappa light chain antibody, specifically engineered to target the retinoic acid receptor alpha (RARα), also known as NR1B1. RARα monoclonal antibody (1C10) is raised against amino acids 315-424 of the human RARα protein. RARα is a pivotal nuclear transcription factor that mediates the effects of retinoic acid, a vital metabolite of vitamin A, playing an essential role in regulating gene expression involved in cell differentiation, proliferation, and apoptosis. The function of RARα is critical for vertebrate development and maintaining tissue homeostasis, and its dysregulation is closely associated with diseases such as acute promyelocytic leukemia (APL), where the RARα gene fuses with the PML gene to form the oncogenic PML/RARα fusion protein. RARα (1C10) antibody exhibits strong reactivity with RARα from mouse, rat, and human sources, making it a versatile tool for various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). By enabling detailed studies of RARα signaling pathways and its involvement in disease mechanisms, RARα (1C10) monoclonal antibody is an indispensable resource for researchers focused on understanding the molecular foundations of development and malignancy.

The preferred RARα/Retinoic Acid Receptor α antibody is RARα/Retinoic Acid Receptor α Antibody (C-1): sc-515796.