Rap1 Antibody (E-11): sc-373790
- Rap1 Antibody (E-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 811-835 near the C-terminus of Rap1 of Saccharomyces cerevisiae origin
- recommended for detection of Rap1 of y origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rap1 Antibody (E-11) for WB applications. These reagents are now offered in bundles with Rap1 Antibody (E-11) (see ordering information below).
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Rap1 Antibody (E-11) is a mouse monoclonal IgG1 antibody that detects RAP1 in various species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RAP1 antibody (E-11) recognizes RAP1, also known as TERF2IP or DRIP5, a 399 amino acid protein located in both the nucleus and cytoplasm, which plays a crucial role in maintaining telomere integrity and regulating transcription. RAP1 contains one BRCT domain and one Myb-like domain, which are essential for its function. RAP1 is recruited to telomeric double-stranded 5′-TTAGGG-3′ repeats through interaction with TRF2, although RAP1 does not bind DNA directly. This recruitment is vital for the negative regulation of telomere recombination and for repressing homology-directed repair, processes that are critical for maintaining telomere length and genomic stability. The gene encoding RAP1 is located on human chromosome 16q23.1 and mouse chromosome 8 E1, highlighting its evolutionary conservation and importance across species.
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Rap1 Antibody (E-11) References:
- Rap1 and SPA-1 in hematologic malignancy. | Kometani, K., et al. 2004. Trends Mol Med. 10: 401-8. PMID: 15310461
- The Rap1-RIAM-talin axis of integrin activation and blood cell function. | Lagarrigue, F., et al. 2016. Blood. 128: 479-87. PMID: 27207789
- Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy. | Cai, Y., et al. 2017. Cell Cycle. 16: 1765-1773. PMID: 28853973
- Role of Rap1 in DNA damage response: implications in stem cell homeostasis and cancer. | Khattar, E. and Tergaonkar, V. 2020. Exp Hematol. 90: 12-17. PMID: 32858091
- Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae. | Rosas Bringas, FR., et al. 2022. Elife. 11: PMID: 35044907
- Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states. | Barry, RM., et al. 2022. Genes Dev. 36: 313-330. PMID: 35210222
- Rap1 prevents fusions between long telomeres in fission yeast. | Pan, L., et al. 2022. EMBO J. 41: e110458. PMID: 36059259
- Rap1 promotes epithelial integrity and cell viability in a growing tissue. | Messer, CL. and McDonald, JA. 2023. Dev Biol. 501: 1-19. PMID: 37269969
- Rap1 regulates lumen continuity via Afadin in renal epithelia. | Hiremath, C., et al. 2023. Dev Biol. 501: 20-27. PMID: 37276970
- Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1. | Ueda, Y., et al. 2023. iScience. 26: 107292. PMID: 37520697
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rap1 Antibody (E-11) | sc-373790 | 200 µg/ml | $316.00 | |||
Rap1 Antibody (E-11): m-IgG Fc BP-HRP Bundle | sc-537872 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rap1 Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-535310 | 200 µg Ab; 40 µg BP | $354.00 | |||
Rap1 Antibody (E-11): m-IgG1 BP-HRP Bundle | sc-545419 | 200 µg Ab; 20 µg BP | $354.00 | |||
Rap1 (E-11) Neutralizing Peptide | sc-373790 P | 100 µg/0.5 ml | $68.00 |