RAP1 Antibody (5G7): sc-47695
- RAP1 Antibody (5G7) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against human RAP1
- recommended for detection of RAP1 of human origin by WB, IP, IF and IHC(P)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for RAP1 Antibody (5G7) for WB and IHC(P) applications. These reagents are now offered in bundles with RAP1 Antibody (5G7) (see ordering information below).
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RAP1 Antibody (5G7) is a mouse monoclonal IgG1 antibody that detects RAP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). RAP1, also known as TERF2IP or DRIP5, is a 399 amino acid protein located in both the nucleus and cytoplasm, featuring one BRCT domain and one Myb-like domain, which are crucial for its function. RAP1 plays a vital role in regulating telomere function and transcription, although RAP1 does not bind directly to DNA. Instead, RAP1 is recruited to telomeric double-stranded 5′-TTAGGG-3′ repeats through interaction with TRF2, highlighting RAP1′s importance in maintaining telomere integrity. Furthermore, RAP1 is essential for negatively regulating telomere recombination and repressing homology-directed repair, processes that are critical for controlling telomere length and stability. The gene encoding RAP1 is located on human chromosome 16q23.1 and mouse chromosome 8 E1, making RAP1 a significant target for studies related to telomere biology and implications in aging and cancer. Anti-RAP1 antibody (5G7) is an invaluable tool for researchers investigating these critical cellular processes.
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RAP1 Antibody (5G7) References:
- The Rap1-RIAM-talin axis of integrin activation and blood cell function. | Lagarrigue, F., et al. 2016. Blood. 128: 479-87. PMID: 27207789
- Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy. | Cai, Y., et al. 2017. Cell Cycle. 16: 1765-1773. PMID: 28853973
- Role of Rap1 in DNA damage response: implications in stem cell homeostasis and cancer. | Khattar, E. and Tergaonkar, V. 2020. Exp Hematol. 90: 12-17. PMID: 32858091
- Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states. | Barry, RM., et al. 2022. Genes Dev. 36: 313-330. PMID: 35210222
- The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells. | Sun, H., et al. 2022. Front Cell Dev Biol. 10: 908622. PMID: 35721481
- Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition. | Kim, YS., et al. 2022. Dev Cell. 57: 1937-1956.e8. PMID: 35998584
- Rap1 regulates lumen continuity via Afadin in renal epithelia. | Hiremath, C., et al. 2023. Dev Biol. 501: 20-27. PMID: 37276970
- Rap1 in the Context of PCSK9, Atherosclerosis, and Diabetes. | Agarwal, H., et al. 2023. Curr Atheroscler Rep. 25: 931-937. PMID: 37979063
- Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. | Yamamoto, K., et al. 2023. FASEB J. 37: e23310. PMID: 38010922
- Presynaptic structural and functional plasticity are coupled by convergent Rap1 signaling. | Kim, YD., et al. 2024. J Cell Biol. 223: PMID: 38748250
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RAP1 Antibody (5G7) | sc-47695 | 200 µg/ml | $322.00 | |||
RAP1 Antibody (5G7): m-IgG Fc BP-HRP Bundle | sc-538935 | 200 µg Ab; 10 µg BP | $361.00 | |||
RAP1 Antibody (5G7): m-IgG1 BP-HRP Bundle | sc-541164 | 200 µg Ab; 20 µg BP | $361.00 |