RANTES Antibody (F-11): sc-514019

RANTES Antibody (F-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects RANTES protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RANTES Antibody (F-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RANTES, also known as C-C Motif Chemokine Ligand 5, plays a crucial role in immune response by acting as a potent chemoattractant for monocytes and natural killer cells, which is vital for orchestrating inflammation and immune surveillance. RANTES is primarily expressed by immune cells such as T lymphocytes, eosinophils, and macrophages, as well as by platelets and endothelial cells, highlighting RANTES importance in both innate and adaptive immunity. RANTES ability to recruit immune cells to sites of inflammation underscores RANTES potential as a therapeutic target in various inflammatory diseases. Additionally, RANTES is characterized by a unique structure that includes a set of conserved cysteine residues, which is a hallmark of the C-C chemokine family, further emphasizing RANTES functional significance in mediating cell signaling and migration.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RANTES Antibody (F-11) References:

1. Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.  |  Liu, H., et al. 1999. Proc Natl Acad Sci U S A. 96: 4581-5. PMID: 10200305
2. RANTES potentiates antigen-specific mucosal immune responses.  |  Lillard, JW., et al. 2001. J Immunol. 166: 162-9. PMID: 11123289
3. Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages.  |  Slimani, H., et al. 2003. Biochim Biophys Acta. 1617: 80-8. PMID: 14637022
4. Upregulating promoter polymorphisms of RANTES relate to atopic dermatitis.  |  Tanaka, K., et al. 2006. Int J Immunogenet. 33: 423-8. PMID: 17117952
5. Targeted delivery of Psc-RANTES for HIV-1 prevention using biodegradable nanoparticles.  |  Ham, AS., et al. 2009. Pharm Res. 26: 502-11. PMID: 19002569
6. CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture.  |  Pattappa, G., et al. 2014. Eur Cell Mater. 27: 124-36; discussion 136. PMID: 24500793
7. Functional role of CCL5/RANTES for HCC progression during chronic liver disease.  |  Mohs, A., et al. 2017. J Hepatol. 66: 743-753. PMID: 28011329
8. Identification of CCL5/RANTES as a novel contraction-reducible myokine in mouse skeletal muscle.  |  Ishiuchi, Y., et al. 2018. Cytokine. 108: 17-23. PMID: 29558694
9. RANTES production in nasal epithelial cells and endothelial cells.  |  Terada, N., et al. 1996. J Allergy Clin Immunol. 98: S230-7. PMID: 8977532
10. Relative role of CSF-1, MCP-1/JE, and RANTES in macrophage recruitment during successful pregnancy.  |  Wood, GW., et al. 1997. Mol Reprod Dev. 46: 62-9; discussion 69-70. PMID: 8981365

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RANTES Antibody (F-11) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-RANTES Antibody (F-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RANTES Antibody (F-11) Specifications

Alternate Product Name: CCL5

Product Clone Name: F-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 24-91

Epitope Target: RANTES

Epitope Species: human

Product Reactivity/Detection: RANTES

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for RANTES Antibody (F-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred RANTES antibody is RANTES Antibody (A-4): sc-365826.