Ral B Antibody (C-8): sc-390108
- Ral B Antibody (C-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 177-206 at the C-terminus of Ral B of rat origin
- Anti-Ral B Antibody (C-8) is recommended for detection of Ral B of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Ral B Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Ral B Antibody (C-8) for WB applications. These reagents are now offered in bundles with Ral B Antibody (C-8) (see ordering information below).
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Ral B Antibody (C-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects RalB in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RalB (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RalB, along with RalA, is part of a unique subfamily of Ras-related GTPases, which are crucial for various cellular processes. These proteins are activated by a specific nucleotide exchange factor known as Ral GDS and are inactivated by distinct GTPase-activating proteins. RalB plays a significant role in regulating cellular signaling pathways, particularly in cancer biology, where RalB has been implicated in promoting cell proliferation and survival. RalB′s ability to interact with downstream effectors, such as Ral BP-1, which contains a Rho-GTPase-activating domain, highlights RalB′s importance in modulating the activity of other GTPases like Cdc42. This interaction is vital for various cellular functions, including cytoskeletal dynamics and cell migration, making RalB a key player in the regulation of cellular behavior in response to external stimuli.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ral B Antibody (C-8) References:
- Involvement of Ral GTPase in v-Src-induced phospholipase D activation. | Jiang, H., et al. 1995. Nature. 378: 409-12. PMID: 7477381
- Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. | Cantor, SB., et al. 1995. Mol Cell Biol. 15: 4578-84. PMID: 7623849
- Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. | Jullien-Flores, V., et al. 1995. J Biol Chem. 270: 22473-7. PMID: 7673236
- Isolation of cDNA clones and tissue expression of rat ral A and ral B GTP-binding proteins. | Wildey, GM., et al. 1993. Biochem Biophys Res Commun. 194: 552-9. PMID: 7687439
- Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap. | Spaargaren, M. and Bischoff, JR. 1994. Proc Natl Acad Sci U S A. 91: 12609-13. PMID: 7809086
- Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. | Hofer, F., et al. 1994. Proc Natl Acad Sci U S A. 91: 11089-93. PMID: 7972015
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ral B Antibody (C-8) | sc-390108 | 200 µg/ml | $316.00 | |||
Ral B Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-530062 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ral B Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-523406 | 200 µg Ab, 40 µg BP | $354.00 | |||
Ral B Antibody (C-8): m-IgG2a BP-HRP Bundle | sc-547425 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ral B Antibody (C-8) AC | sc-390108 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Ral B Antibody (C-8) HRP | sc-390108 HRP | 200 µg/ml | $316.00 | |||
Ral B Antibody (C-8) FITC | sc-390108 FITC | 200 µg/ml | $330.00 | |||
Ral B Antibody (C-8) PE | sc-390108 PE | 200 µg/ml | $343.00 | |||
Ral B Antibody (C-8) Alexa Fluor® 488 | sc-390108 AF488 | 200 µg/ml | $357.00 | |||
Ral B Antibody (C-8) Alexa Fluor® 546 | sc-390108 AF546 | 200 µg/ml | $357.00 | |||
Ral B Antibody (C-8) Alexa Fluor® 594 | sc-390108 AF594 | 200 µg/ml | $357.00 | |||
Ral B Antibody (C-8) Alexa Fluor® 647 | sc-390108 AF647 | 200 µg/ml | $357.00 | |||
Ral B Antibody (C-8) Alexa Fluor® 680 | sc-390108 AF680 | 200 µg/ml | $357.00 | |||
Ral B Antibody (C-8) Alexa Fluor® 790 | sc-390108 AF790 | 200 µg/ml | $357.00 | |||
Ral B (C-8) Neutralizing Peptide | sc-390108 P | 100 µg/0.5 ml | $68.00 |