RAIDD Antibody (G-7): sc-377080
- RAIDD Antibody (G-7) is a mouse monoclonal IgG1 κ RAIDD antibody provided at 200 µg/ml
- raised against amino acids 1-199 representing full length RAIDD (RIP-associated ICH-1/Ced-3 homologous protein with a death domain) (RIP-associated ICH-1/Ced-3 homologous protein with a death domain) of mouse origin
- RAIDD Antibody (G-7) is recommended for detection of RAIDD of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-RAIDD Antibody (G-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RAIDD Antibody (G-7) for WB applications. These reagents are now offered in bundles with RAIDD Antibody (G-7) (see ordering information below).
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RAIDD Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects RAIDD protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RAIDD antibody (G-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RAIDD, or RIP-associated ICH-1/Ced-3 homologous protein with a death domain, plays a crucial role in apoptosis by linking tumor necrosis factor receptors (TNFRs) to the caspase activation cascade. RAIDD contains a death domain that is essential for interaction with other death domain-containing proteins, such as receptor interacting protein (RIP) and TNF-R1 binding protein TRADD. This interaction facilitates the recruitment of caspases, which are cysteine proteases that execute programmed cell death. RAIDD′s amino-terminal domain shares significant homology with the prodomain of ICH-1, enhancing binding to caspases and further emphasizing importance in apoptosis regulation. RAIDD monoclonal antibody (G-7) enables researchers to gain valuable insights into cell death mechanisms and intricate signaling pathways involved in apoptosis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RAIDD Antibody (G-7) References:
- Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly. | Park, HH. and Wu, H. 2006. J Mol Biol. 357: 358-64. PMID: 16434054
- Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD. | Park, HH. and Wu, H. 2007. Acta Crystallogr Sect F Struct Biol Cryst Commun. 63: 229-32. PMID: 17329820
- FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. | Chinnaiyan, AM., et al. 1995. Cell. 81: 505-12. PMID: 7538907
- RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. | Stanger, BZ., et al. 1995. Cell. 81: 513-23. PMID: 7538908
- Contenders in FasL/TNF death signaling. | Cleveland, JL. and Ihle, JN. 1995. Cell. 81: 479-82. PMID: 7758103
- The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. | Hsu, H., et al. 1995. Cell. 81: 495-504. PMID: 7758105
- A novel domain within the 55 kd TNF receptor signals cell death. | Tartaglia, LA., et al. 1993. Cell. 74: 845-53. PMID: 8397073
- Transducers of life and death: TNF receptor superfamily and associated proteins. | Baker, SJ. and Reddy, EP. 1996. Oncogene. 12: 1-9. PMID: 8552378
- RAIDD is a new 'death' adaptor molecule. | Duan, H. and Dixit, VM. 1997. Nature. 385: 86-9. PMID: 8985253
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RAIDD Antibody (G-7) | sc-377080 | 200 µg/ml | $322.00 | |||
RAIDD Antibody (G-7): m-IgG Fc BP-HRP Bundle | sc-529969 | 200 µg Ab; 10 µg BP | $361.00 | |||
RAIDD Antibody (G-7): m-IgGκ BP-HRP Bundle | sc-523177 | 200 µg Ab, 40 µg BP | $361.00 | |||
RAIDD Antibody (G-7): m-IgG1 BP-HRP Bundle | sc-543795 | 200 µg Ab; 20 µg BP | $361.00 | |||
RAIDD Antibody (G-7) AC | sc-377080 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RAIDD Antibody (G-7) HRP | sc-377080 HRP | 200 µg/ml | $322.00 | |||
RAIDD Antibody (G-7) FITC | sc-377080 FITC | 200 µg/ml | $336.00 | |||
RAIDD Antibody (G-7) PE | sc-377080 PE | 200 µg/ml | $349.00 | |||
RAIDD Antibody (G-7) Alexa Fluor® 488 | sc-377080 AF488 | 200 µg/ml | $364.00 | |||
RAIDD Antibody (G-7) Alexa Fluor® 546 | sc-377080 AF546 | 200 µg/ml | $364.00 | |||
RAIDD Antibody (G-7) Alexa Fluor® 594 | sc-377080 AF594 | 200 µg/ml | $364.00 | |||
RAIDD Antibody (G-7) Alexa Fluor® 647 | sc-377080 AF647 | 200 µg/ml | $364.00 | |||
RAIDD Antibody (G-7) Alexa Fluor® 680 | sc-377080 AF680 | 200 µg/ml | $364.00 | |||
RAIDD Antibody (G-7) Alexa Fluor® 790 | sc-377080 AF790 | 200 µg/ml | $364.00 |